%0 Journal Article %T The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial %J Iranian Journal of Immunology %I Shiraz Institute for Cancer Research %Z 1735-1383 %A Kilic, Ayse %A Yener, Gulcin Otar %A Yetim, Aylin %A Ozcetin, Mustafa %A Gokcay, Gulbin %A Coban, Asuman %A Ince, Zeynep %A Yasa, Beril %A Oksuz, Lutfiye %A Ugurlucan, Funda Gungor %A Gurler, Nezahat %D 2019 %\ 09/25/2019 %V 16 %N 3 %P 225-234 %! The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial %K Infant %K Maternal Immunization %K Pertussis Vaccine %R 10.22034/iji.2019.80273 %X Background: Despite primary vaccination, infants under six months run a risk of infection with pertussis. Objective: To determine the impact of early postpartum maternal pertussis vaccination on protecting infants from the disease. Methods: All mothers (n=405) who gave birth to healthy term infants were educated on the cocoon strategy. The mothers who consented were immunized with the tetanus-diphtheria-acellular pertussis vaccine within the first three postpartum days. All infants received their pertussis vaccines according to the national schedule. The anti-pertussis IgG titers of infants of thirty vaccinated mothers were compared with those of thirty unvaccinated mothers. Results: The pertussis antibody levels in the infants of vaccinated mothers were significantly higher than those of unvaccinated mothers at the mean infant age of 5.6 ± 1.2 months. Only 6 infants of vaccinated mothers exhibited pertussis-like symptoms, none of whom had positive pertussis PCR. Seventeen infants of unvaccinated mothers had pertussis-like symptoms, and 4 tested positive for pertussis PCR. Conclusion: Our results showed that maternal pertussis vaccination, administered within the first three postpartum days, may protect infants against pertussis in their first ten months. %U https://iji.sums.ac.ir/article_45569_5420465994cf7a14b8da8e82e137fa40.pdf