TY - JOUR ID - 16764 TI - Negative Association of Serum IL-6 and IL-17 with Type-II Diabetes Retinopathy JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Afzal, Nadeem AU - Zaman, Shakeela AU - Asghar, Aneela AU - Javed, Khursheed AU - Shahzad, Faheem AU - Zafar, Abu AU - Hanan Nagi, Abdul AD - Department of Immunology, University of Health Sciences AD - Children Hospital and Institute of Child Health, Lahore AD - Department of Biochemistry, Sahiwal Medical College, Sahiwal AD - Amin Hayat Memorial Diabetic Centre, Lahore AD - Departments of Pathology, University of Health Sciences, Lahore, Pakistan Y1 - 2014 PY - 2014 VL - 11 IS - 1 SP - 40 EP - 48 KW - Cytokine KW - diabetes mellitus KW - Inflammation KW - Retinopathy DO - N2 - Background: Diabetes mellitus (DM) is a health concern which leads to complications such as retinopathy. Pakistan has 6.9 million people living with DM and this toll will be doubled by 2025. Objective: To determine serum IL-6 and IL-17 of type 2 diabetes mellitus (T2DM) patients with retinopathy. Methods: In this cross-sectional casecontrol study, 212 subjects enrolled which were categorized into 3 groups. Group-I included 30 subjects without diabetes, group-II consisted of 30 subjects with T2DM without retinopathy and group-III consisted of 152 subjects with T2DM and retinopathy. Serum IL-6 and IL-17 levels were determined by ELISA. Data was analysed using SPSS 17.0 and one way ANOVA to observe group mean differences. Results: Longer mean duration of disease was detected in group-III than group-II (p=0.007). Highest IL-6 level was detected in group-II and highest IL-17 level was detected in group-I. For IL-6, significant differences were detected among groups in total, between Group-I and Group-III and between Group-II and Group-III (p<0.0001 each). Regarding IL-17, significant differences were found among groups in total (p=0.002) and between Group-I and Group-III (p=0.001). No significant difference in the percentages of HbA1c observed between groups. Conclusions: Age, gender and duration of diabetes contribute to T2DM retinopathy. Serum IL-6 and IL-17 were inversely associated with T2DM retinopathy. UR - https://iji.sums.ac.ir/article_16764.html L1 - https://iji.sums.ac.ir/article_16764_1f620dd06ee10f180364ff5faa2446df.pdf ER -