TY - JOUR ID - 16786 TI - Analysis of Serum Cytokine Levels in Larynx Squamous Cell Carcinoma and Dysplasia Patients JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Eyigor, Mete AU - Eyigor, Hulya AU - Osma, Ustun AU - Yilmaz, MustafaDeniz AU - Erin, Nuray AU - Selcuk, Omer Tarik AU - Sezer, Cem AU - Gultekin, Meral AU - Koksoy, Sadi AD - Akdeniz University Medical Faculty, Department of Medical Microbiology AD - Department of ENT Head and Neck Surgery, Antalya Education and Research Hospital AD - Akdeniz University Medical Faculty, Department of Medical Pharmacology AD - Department of Pathology, Antalya Education and Research Hospital, Antalya, Turkey Y1 - 2014 PY - 2014 VL - 11 IS - 4 SP - 259 EP - 268 KW - Bead Array KW - Cytokine KW - Dysplasia KW - HNSCC KW - Larynxm Carcinoma DO - N2 - Background: Although the imbalance of cytokines in Head and Neck Squamous Cell Carcinoma (HNSCC) is well known, there is scarce data regarding its occurrence during dysplasia, before the malignant transformation. Objective: To determine whether laryngeal dysplasia patients show a different cytokine profile than patients with cancer and healthy controls. Methods: Seventeen newly diagnosed, untreated larynx squamous cell carcinoma (SCC) and six laryngeal dysplasia patients as well as 22 healthy controls were analyzed for circulating cytokines. A flowcytometry Th1/Th2 cytokine array kit was used to quantitatively measure Interleukin-2 (IL-2), IL-4, IL-6, IL-10, Tumor Necrosis Factor-α (TNF-α) and Interferon-γ (IFN-γ) levels. Additionally, IL-8 levels were determined through ELISA. Results: IL-6, IL-8 and IL-10 were determined to be statistically increased in SCC patients (p<0.05). IL-8 and IL-10 levels were also higher in SCC patients than dysplasia patients (p<0.05). Additionally, IL-6 and IL-10 were all found to be markedly increased in dysplasia patients compared with controls (p<0.05). Conclusion: Our results demonstrate an imbalance of IL-6 and IL-10 not only in HNSCC but also in laryngeal dysplasia. UR - https://iji.sums.ac.ir/article_16786.html L1 - https://iji.sums.ac.ir/article_16786_c6e88da9f558d773a7abdfd40659951d.pdf ER -