TY - JOUR ID - 16788 TI - Aqueous Humor and Serum Concentrations of Soluble MICA and MICB in Glaucoma Patients JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Nowroozpoor-Dailami, Kiomars AU - Mirabi, Araz-Mohammad AU - Tehrani, Mohsen AU - Ajami, Abolghasem AD - Department of Ophthalmology, Bou Ali Sina Hospital AD - Department of Immunology, School of Medicine AD - Department of Immunology, School of Medicine Y1 - 2014 PY - 2014 VL - 11 IS - 4 SP - 275 EP - 281 KW - Aqueous Humor KW - Glaucoma KW - MICA KW - MICB DO - N2 - Background: Immune reactions have been reported to be involved in the destruction of retinal ganglion cells (RGCs) in glaucoma. Objective: To investigate the role of major histocompatibility complex class I-related chain A and B (MICA and MICB) molecules in the pathogenesis of glaucoma. Methods: Aqueous humor and serum samples from 15 glaucoma patients and 45 patients with cataract, undergoing ocular surgery, were obtained. The concentrations of MICA and MICB molecules in all samples were measured using ELISA. Results: Both MICA and MICB concentrations were higher in the aqueous humor of patients with glaucoma compared to those with cataract (p=0.013 and p=0.004, respectively); however, in the serum samples, no significant differences were observed. Conclusions: Increased intraocular pressure may be associated with increased expression of the MICA and MICB molecules, which could initiate the destruction of RGCs and consequent development of glaucoma. UR - https://iji.sums.ac.ir/article_16788.html L1 - https://iji.sums.ac.ir/article_16788_f91edd6fd731d9e1296fe7b0ea07db54.pdf ER -