TY - JOUR ID - 16960 TI - Determination of Soluble HER-2/neu (sHER-2/neu) in Iranian Patients with Lung Cancer JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Ghayumi, Seyyed Mohammad Ali AU - Aghasadeghi, Kambiz AU - Dorouchi, Mehrnoosh AU - Ghaderi, Abbas AD - Department of Internal Medicine AD - Department of Immunology AD - Department of Immunology Y1 - 2006 PY - 2006 VL - 3 IS - 2 SP - 61 EP - 65 KW - Lung Cancer KW - HER2/neu KW - Iran DO - N2 - Background: The HER-2/neu gene is located on chromosome 17q21 and encodes a 185-kDa transmembrane glycoprotein with tyrosine kinase activity reported to be released in soluble form in various malignancies. Objective: To evaluate the clinical significance of soluble Her-2/neu as a diagnostic marker in lung cancer. Methods: Serum levels of soluble HER-2/neu were measured in 43 patients with lung cancer and 42 age and sex matched controls by an enzyme immunoassay method. Results: Mean serum level of soluble Her-2/neu in cancer patients was 6.07±10.37 ng/ml which was significantly higher than the control group (P < 0.05). Cigarette smoking had no effect on the level of soluble HER-2/neu. A cut off value of 6.1ng/ml revealed a high specificity (95%) for diagnosis of lung cancer, but a very low sensitivity (14%). Conclusion: The results of this study show an increased level of soluble HER-2/neu in the sera of lung cancer patients with a high specificity but low sensitivity for diagnosis of lung cancers. UR - https://iji.sums.ac.ir/article_16960.html L1 - https://iji.sums.ac.ir/article_16960_6b1cfccfbda77efb374c1aff69b03d4b.pdf ER -