TY - JOUR ID - 17035 TI - KIR2DS3 is Associated with Protection against Acute Myeloid Leukemia JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Shahsavar, Farhad AU - Tajik, Nader AU - Entezami, Kobra-Zinat AU - Fallah Radjabzadeh, Masoomeh AU - Asadifar, Behnam AU - Alimoghaddam, Kamran AU - Ostadali Dahaghi, Mohammadreza AU - Jalali, Arash AU - Ghashghaie, Andisheh AU - Ghavamzadeh, Ardeshir AD - Division of Transplant Immunology and Immunogenetics, Department of Immunology, Iran University of Medical Sciences, Tehran, Iran AD - Division of Transplant Immunology and Immunogenetics, Department of Immunology, Iran University of Medical Sciences, Tehran, Iran AD - Hematology-Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Hematology-Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Y1 - 2010 PY - 2010 VL - 7 IS - 1 SP - 8 EP - 17 KW - Acute Leukemia KW - Genotype KW - HLA KW - KIR DO - N2 - Background: Interaction between killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen (HLA) class I molecules is important for regulation of natural killer (NK) cell function. Objective: The aim of this study was to investigate the impact of compound KIR-HLA genotype on susceptibility to acute leukemia. Methods: Cohorts of Iranian patients with acute myeloid leukemia (AML; n=40) and acute lymphoid leukemia (ALL; n=38) were genotyped for seventeen KIR genes and their three major HLA class I ligand groups (C1, C2, Bw4) by a combined polymerase chain reaction–sequence-specific primers (PCR-SSP) assay. The results were compared with those of 200 healthy control individuals. Results: We found a significantly decreased frequency of KIR2DS3 in AML patients compared to control group (12.5% vs. 38%, odds ratio=0.23, p=0.0018). Also, the KIR3DS1 was less common in AML group than controls (27.5% vs. 44.5%, p=0.0465, not significant after correction). Other analyses including KIR genotypes, distribution and balance of inhibitory and activating KIR+HLA combinations, and co-inheritance of activating KIR genes with inhibitory KIR+HLA pairs were not significantly different between leukemia patients and the control group. However, in AML patients a trend toward less activating and more inhibitory KIR-HLA state was observed. Interestingly, this situation was not found in ALL patients and inhibition enhancement through increase of HLA ligands and inhibi-tory combinations was the main feature in this group. Conclusion: Our findings may suggest a mechanism for escape of leukemic cells from NK cell immunity. UR - https://iji.sums.ac.ir/article_17035.html L1 - https://iji.sums.ac.ir/article_17035_2ae84eeb0b534347ce5d1ef9f5be0168.pdf ER -