TY - JOUR ID - 17171 TI - Comparison of the Salivary Immu-noglobulin Concentration Levels between Children with Early Childhood Caries and Caries-Free Children JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Bagherian, Ali AU - Jafarzadeh, Abdullah AU - Rezaeian, Mohsen AU - Ahmadi, Shima AU - Rezaity, Mohammad Taghi AD - Department of Pediatric Dentistry, Dental School AD - Department of Immunology AD - Department of Epidemiology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Y1 - 2008 PY - 2008 VL - 5 IS - 4 SP - 217 EP - 221 KW - dental caries KW - immunoglobulins KW - Saliva DO - N2 - Background: Early Childhood Caries (ECC) is one of the most common chronic child-hood diseases. In spite of the global decrease in dental caries in the past decades, ECC has become a significant problem in many developing countries and also in a few indus-trialized nations. Saliva as a host factor can play an important role in the process of den-tal caries. Objective: The aim of this study was to compare sIgA and IgG as saliva components between ECC and caries-free groups. Methods: In this cross-sectional study, samples of unstimulated saliva of 90 children (45 in ECC group & 45 in caries-free group) were taken with Scully method. Then the concentration levels of sIgA and IgG were measured with Enzyme Linked Immunosorbent Assay and Single Radial Im-munodiffusion methods. Results: Mean concentration levels of salivary sIgA and IgG were significantly higher among children with ECC (p<0.05). There was also a weak inverse correlation between sIgA level and DMFT index in ECC group but it was not statistically significant (p=0.056). Conclusion: The high concentration of salivary im-munoglobulin in children with ECC may be associated with an increased antigenic load, leading to high production of antibodies. UR - https://iji.sums.ac.ir/article_17171.html L1 - https://iji.sums.ac.ir/article_17171_d67d133dc09e94a028db11cdd2b7d547.pdf ER -