TY - JOUR ID - 17196 TI - Serum Cytokines Profiles in Iranian Patients with Preeclampsia JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Mansouri, Reza AU - Akbari, Firoozeh AU - Vodjgani, Mohammad AU - Mahboudi, Fereidoun AU - Kalantar, Fathollah AU - Mirahmadian, Mahroo AD - Department of Immunology, School of Medicine, Medical sciences / University of Tehran AD - Department of Obstetrics and Gynaecology, School of Medicine, Medical sciences / University of Tehran AD - Biotechnology Research Center, Pasteur Institute of Iran, Tehran Iran Y1 - 2007 PY - 2007 VL - 4 IS - 3 SP - 179 EP - 185 KW - Preeclampsia KW - Cytokines KW - ELISA DO - N2 - Background: Preeclampsia is a major cause of mortality and morbidity and is also a leading cause of preterm birth and intrauterine growth retardation. Several studies have reported abnormal levels of cytokines in women with preeclampsia. Objectives: To detect serum levels of various cytokines in pregnant women with and without preeclampsia in the third trimester of pregnancy. Methods: Thirty patients with preeclampsia and thirty normal pregnant women were enrolled in the study. Blood samples were taken and serum levels of IFN γ, IL-12p70, IL-18, IL-15, IL-4 and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA). Results: Preeclamptic women had significantly increased levels of circulating IL-12p70 (p < 0.05), IL-18 (p < 0.001), IL-4 (p < 0.001), IL-15 (p < 0.05) and IFN γ (p < 0.001). By contrast, circulating levels of IL-10 were not significantly different between the two groups. Conclusions: The present study supports the hypothesis of altered immune response in preeclampsia and suggests that dysregulation of cytokine expression occurs in preeclampsia with increased levels of IFN γ, IL-12p70, IL-15, IL-18 and IL-4. UR - https://iji.sums.ac.ir/article_17196.html L1 - https://iji.sums.ac.ir/article_17196_ed35a8f78cf7e1a971ec261796f5514f.pdf ER -