TY - JOUR ID - 45974 TI - IL-25 and IL-33 Serum Levels are not Associated with the Type of Allergen Causing Allergic Rhinitis JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Abbasi, Reza AU - Zomorodian, Kamiar AU - Zare Shahrabadi, Zahra AU - Saadat, Farshid AU - Nabavizadeh, Seyed Hesamedin AU - Esmaeilzadeh, Hossein AU - Alyasin, Sohila AD - Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AD - Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Parasitology and Mycology, School of Public Health, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Immunology, School of Public Health, Guilan University of Medical Sciences, Guilan, Iran Y1 - 2019 PY - 2019 VL - 16 IS - 4 SP - 321 EP - 326 KW - Allergic Fungal Sinusitis KW - Interleukin-25 KW - Interleukin-33 KW - IgE DO - 10.22034/iji.2019.80283 N2 - Background: Fungal aeroallergens might sensitize the airway which in turn produces a specific cytokine profile. Objective: To evaluate the IL-25 and IL-33 profile in patients with fungal allergic rhinitis. Methods: The present study examined patients who were evaluated due to allergic rhinitis (AR) at Emam Reza Hospital of Shiraz, Iran. The allergic patients were categorized based on the skin prick test. Blood samples were collected and allergen-specific IgE and cytokine profiles were analyzed. Results: 184 patients were enrolled in the study and in 35 of whom fungal rhinitis was confirmed. The levels of specific IgE in patients with fungal allergy were statistically significant compared to those in the control group (p<0.000). However, there were no significant differences in IL-25 and IL-33 levels between fungal and none-fungal AR patients. Conclusion: Chronic fungal challenge might regulate innate system cytokines in severe persistent AR. UR - https://iji.sums.ac.ir/article_45974.html L1 - https://iji.sums.ac.ir/article_45974_676cd791d56b638d51c756753b25e6f1.pdf ER -