Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
1. Vaccination with Live Attenuated L. Major and TLR4 Agonist Promotes a Th1 Immune Response and Induces Protection against L. Major Infection in BALB/c Mice

Shamsi Noorpisheh Ghadimi; Shirin Farjadian; Gholam Reza Hatam; Mehdi Kalani; Bahador Sarkari

Volume 15, Issue 2 , Spring 2018, , Pages 74-83


  Background: Toll like receptors play a major role in immune responses against Leishmania parasites. Objective: To evaluate the efficacy of vaccination with live attenuated L. major and TLR4 agonist in protection against L. major infection. Methods: Attenuated L. major was prepared by continuous sub-culturing ...  Read More

2. Natural Killer Cell Cytotoxicity Against SKOV3 after HLA-G Downregulation by shRNA

Nazanin Nazari; Shirin Farjadian

Volume 13, Issue 3 , Summer 2016, , Pages 178-185

  Background: HLA-G is a nonclassical HLA class I molecule which, when elevated in tumor cells, is one of the main factors involved in tumor evasion of immune responses including NK and T cells. Objective: To evaluate the effect of HLA-G downregulation on NK cell cytotoxicity in tumor cell lines. Methods: ...  Read More

3. Effect of Thermal Stress on MICA/B Induction in a Human Liposarcoma Cell Line

Shirin Farjadian; Shahrzad Rahimifar; Nasrollah Erfani; Ramin Lotfi

Volume 10, Issue 1 , Winter 2013, , Pages 31-39

  Background: A possible mechanism by which hyperthermia enhances tumor immunogenicity is the induction of NKG2D ligands on tumor cells. Although the expression of MHC class I chain-related protein A and B (MICA/B) has previously been reported in different carcinomas, there is no information about MICA/B ...  Read More

4. Specific IgE to Common Food Allergens in Children with Atopic Dermatitis

Mozhgan Moghtaderi; Shirin Farjadian; Sara Kashef; Soheila Alyasin; Maryam Afrasiabi; Marzieh Orooj

Volume 9, Issue 1 , Winter 2012, , Pages 32-38

  Background: Atopic dermatitis is a major public health problem, often starting in early childhood and sometimes followed by other allergic diseases. Although hypersensitivity to foods is assumed to play an essential role in the development of atopic dermatitis in some patients, little is known about ...  Read More

5. Association of HLA-DQA1*0101/2 and DQB1*0502 with Myasthenia Gravis in Southern Iranian Patients

Gholam-Ali Yousefipour; Zahra Salami; Shirin Farjadian

Volume 6, Issue 2 , Spring 2009, , Pages 99-102

  Background: Myasthenia gravis is an autoimmune disorder of neuromuscular junction characterized by skeletal muscle weakness and fatigability. Different genes may control the induction and clinical presentation of this disease. Various HLA alleles are reported as predisposing or protective genetic elements ...  Read More

6. Antigen-Specific Antibody Response in Juvenile-Onset SLE Patients Following Routine Immunization with Tetanus Toxoid

Sara Kashef; Farid Ghazizadeh; Ali Derakhshan; Shirin Farjadian; Soheila Alyasin

Volume 5, Issue 3 , Summer 2008, , Pages 181-184

  Background: Infection is now the most common cause of morbidity in Systemic Lupus Erythematosus (SLE). There is lack of information regarding the specific antibody forma-tion in response to vaccines in young SLE patients. Objective: To determine the efficacy of anti-tetanus antibody response in young ...  Read More

7. Analysis of Human Leukocyte Antigen class II Gene Polymorphism in Iranian Patients with Papillon-Lefevre Syndrome: a Family Study

Shirin Farjadian; Mehrdad Lotfazar; Abbas Ghaderi

Volume 5, Issue 3 , Summer 2008, , Pages 171-176

  Background: Papillon-Lefevre syndrome (PLS) is a rare autosomal recessive disorder characterized by palmoplantar hyperkeratosis and early development of aggressive pe-riodontitis. Although cathepsin C (CTSC) gene mutations have been established in about 70-80% of PLS patients, it is assumed that the ...  Read More

8. HLA Class I Gene Polymorphism in Iranian Patients with Papillon-Lefevre Syndrome

Shirin Farjadian; Nasrin Kiyanimanesh; Abbas Abbaszadegan; Mehrdad Lotfazar

Volume 4, Issue 4 , Autumn 2007, , Pages 241-245

  Background: Papillon-Lefevre Syndrome (PLS) is a rare autosomal recessive disorder characterized by diffused palmoplantar keratoderma and severe periodontitis. Increased susceptibility to infections due to impairment of the immune system is considered to be involved in pathoetiology of this disease. ...  Read More

9. HLA class II Genetic Diversity in Arabs and Jews of Iran

Shirin Farjadian; Abbas Ghaderi

Volume 4, Issue 2 , Spring 2007, , Pages 85-93

  Background: Anthropological studies based on highly polymorphic HLA genes pro-vide useful information for bone marrow donor registry, forensic medicine, disease as-sociation studies, as well as designing peptide vaccines against tumors, and infectious or autoimmune diseases. Objective: This study was ...  Read More

10. Iranian Lurs Genetic Diversity: An Anthropological View Based on HLA Class II Profiles

Shirin Farjadian; Abbas Ghaderi

Volume 3, Issue 3 , Summer 2006, , Pages 106-113

  Background: HLA genes are highly polymorphic and certain alleles are frequent only in specific populations. Therefore, HLA is a unique tool for studying the genetic relationship between different populations. Iranians are ethnically diverse people and one of the major ethnic groups in Iran is Lur population ...  Read More