Reza Abbasi; Kamiar Zomorodian; Zahra Zare Shahrabadi; Farshid Saadat; Seyed Hesamedin Nabavizadeh; Hossein Esmaeilzadeh; Sohila Alyasin
Abstract
Background: Fungal aeroallergens might sensitize the airway which in turn produces a specific cytokine profile. Objective: To evaluate the IL-25 and IL-33 profile in patients with fungal allergic rhinitis. Methods: The present study examined patients who were evaluated due to allergic rhinitis (AR) at ...
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Background: Fungal aeroallergens might sensitize the airway which in turn produces a specific cytokine profile. Objective: To evaluate the IL-25 and IL-33 profile in patients with fungal allergic rhinitis. Methods: The present study examined patients who were evaluated due to allergic rhinitis (AR) at Emam Reza Hospital of Shiraz, Iran. The allergic patients were categorized based on the skin prick test. Blood samples were collected and allergen-specific IgE and cytokine profiles were analyzed. Results: 184 patients were enrolled in the study and in 35 of whom fungal rhinitis was confirmed. The levels of specific IgE in patients with fungal allergy were statistically significant compared to those in the control group (p<0.000). However, there were no significant differences in IL-25 and IL-33 levels between fungal and none-fungal AR patients. Conclusion: Chronic fungal challenge might regulate innate system cytokines in severe persistent AR.
Soheila Alyasin; Reza Amin; Ali Fazel; Mohammad Hossein Karimi; Seyed Hesamedin Nabavizadeh; Hossein Esmaeilzadeh; Maryam Babaei
Volume 14, Issue 1 , March 2017, , Pages 73-80
Abstract
Background: Asthma is the chronic inflammation of airways characterized by eosinophilic infiltration, mucus overproduction, airway hyper-responsiveness and airway remodeling. These changes are induced mostly by cytokines which are produced by T helper (Th) 2 cells. Recently, the role of interleukin-23 ...
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Background: Asthma is the chronic inflammation of airways characterized by eosinophilic infiltration, mucus overproduction, airway hyper-responsiveness and airway remodeling. These changes are induced mostly by cytokines which are produced by T helper (Th) 2 cells. Recently, the role of interleukin-23 (IL-23) in the pathogenesis of adultallergic asthma has been studied. Objective: To explore IL-23 serum levels and its expression in persistent asthma compared with healthy children younger than five years old. Method: Blood samples of 40 children with mild and severe persistent asthma were compared to 34 healthy children regarding IL-23 serum levels and gene expression using enzyme-linked immunosorbentassay (ELISA) and real time quantitative polymerase chain reaction (PCR). Results: The IL-23 gene expression level was significantly different in the 25 children with mild persistent asthma and the 15 children with severe persistent asthma compared to the control group (p=0.001).There was no significant difference in IL-23 gene expression level between the two groups of patients with mild and severe persistent asthma. A significant difference was seen in IL-23 serum levels between the 25 children with persistent asthma and control group (p=0.002).Conclusion: For pre-school children with history and physical exam in favor of asthma which cannot be tested by spirometry, IL-23 serum levels may be an auxiliary biomarker for the diagnosis of asthma.
Hossein Esmaeilzadeh; Elmira Esmaeilzadeh; Mohammad Faramarzi; Mohammad Nabavi; Mohammad Farhadi
Volume 14, Issue 1 , March 2017, , Pages 81-88
Abstract
Background: A clear association between allergy and nasal polyposis (NP) is not
determined and the role of food intolerance in patients with NP is not investigated by
oral food challenge (OFC). Objective: To investigate the relation of salicylate food
intolerance and atopy in patients with NP according ...
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Background: A clear association between allergy and nasal polyposis (NP) is not
determined and the role of food intolerance in patients with NP is not investigated by
oral food challenge (OFC). Objective: To investigate the relation of salicylate food
intolerance and atopy in patients with NP according to recurrence and aspirin
sensitivity. Methods: A cross sectional multicenter study was done in two tertiary
centers for allergy in Iran. Adult patients with NP were selected for the study that had
been referred to allergy clinics. The oral aspirin challenge (OAC) test was performed to
identify aspirin exacerbated respiratory disease (AERD) and the OFC test was used to
investigate food intolerance. Atopic evaluation was performed by skin-prick tests, nasal
smear and blood eosinophil count as well as serum total IgE. Results: One hundred and
nineteen Iranian patients (female to male ratio 1.05) with NP were enrolled (mean age,
38 ± 11 years). Recurrence of nasal polyposis was 64.7%. OAC was performed in all
cases; 43.79% cases had aspirin hypersensitivity. In addition, OFC tests determined that
69.9% of patients had salicylate food allergy. Salicylate food intolerance was
significantly higher in NP cases with AERD than in aspirin tolerant patients (p<0.05).
Yet, positive skin prick test was not associated with NP recurrence and AERD.
Conclusion: Atopy and NSAID exacerbated respiratory disease; therefore, they can
both be considered as predictors of NP recurrence. Our study also showed that salicylate
food intolerance was associated with AERD in nasal polyposis.