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1. Vaccination with Live Attenuated L. Major and TLR4 Agonist Promotes a Th1 Immune Response and Induces Protection against L. Major Infection in BALB/c Mice

Shamsi Noorpisheh Ghadimi; Shirin Farjadian; Gholam Reza Hatam; Mehdi Kalani; Bahador Sarkari

Volume 15, Issue 2 , Spring 2018, , Pages 74-83

http://dx.doi.org/10.22034/iji.2018.39372

Abstract
  Background: Toll like receptors play a major role in immune responses against Leishmania parasites. Objective: To evaluate the efficacy of vaccination with live attenuated L. major and TLR4 agonist in protection against L. major infection. Methods: Attenuated L. major was prepared by continuous sub-culturing ...  Read More