Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)

Aim and scope:
The Iranian Journal of Immunology (I.J.I) is an internationally disseminated peer-reviewed publication and publishes a broad range of experimental and theoretical studies concerned with all aspects of immunology.

Types of papers accepted:
The Journal will welcome original and review articles on basic and clinical Immunology, Immunogenetics, Transplantation Immunology, Immunohematology, Cancer Immunology, and Allergy. The Journal will also welcome short papers and letters to the Editor.

Iranian Journal of Immunology is indexed in the following indexing systems: 

  • Web of Science (ISI)
  • EMNursing
  • Cambridge Scientific Abstracts
  • Chemical Abstracts
  • Global Health
  • Index Medicus for Eastern Mediterranean Region (IMEMR)

And is approved by Medical Journals Commission of the Ministry of Health and Medical Education.

Original Article
1. Hepcidin Induces M1 Macrophage Polarization in Monocytes or THP-1 Derived Macrophages

Enna Liu; Zheng Li; Yan Zhang; Kuisheng Chen

Volume 16, Issue 3 , Summer 2019, Pages 190-199


  Background: Macrophage polarization plays a critical role in determining the inflammatory states. Hepcidin is a key negative regulator of iron homeostasis and functions. Although hepcidin has been shown to affect ferroportin expression in macrophages, whether it affects macrophage polarization is still ...  Read More

Original Article
2. Immunogenic Evaluation of Bivalent Vaccine Candidate against Enterohemorrhagic and Enterotoxigenic Escherichia coli

Ahmad Karimi Rahjerdi; Mahyat Jafari; Mohammad Javad Motamedi; Jafar Amani; Ali Hatef Salmanian

Volume 16, Issue 3 , Summer 2019, Pages 200-211


  Background: Caused by bacterial, viral, and parasitic pathogens, diarrhea is the second leading cause of death among children under five. Two strains of E. coli, namely Enterotoxigenic, ETEC and Enterohemorrhagic EHEC are the most important causes of this disease in developing countries. EHEC is a major ...  Read More

Original Article
3. IpaD-loaded N-trimethyl Chitosan Nanoparticles Can Efficiently Protect Guinea Pigs against Shigella Flexneri

Mohammad Reza Akbari; Mojtaba Saadati; Hosein Honari; Hadi Mohammad Ghorbani

Volume 16, Issue 3 , Summer 2019, Pages 212-224


  Background: Shigella flexneri is a pathogen responsible for shigellosis around the world, especially in developing countries. Many immunogenic antigens have been introduced as candidate vaccines against Shigella, including N-terminal region of IpaD antigen (NIpaD). Objective: To evaluate the efficiency ...  Read More

Original Article
4. The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial

Ayse Kilic; Gulcin Otar Yener; Aylin Yetim; Mustafa Ozcetin; Gulbin Gokcay; Asuman Coban; Zeynep Ince; Beril Yasa; Lutfiye Oksuz; Funda Gungor Ugurlucan; Nezahat Gurler

Volume 16, Issue 3 , Summer 2019, Pages 225-234


  Background: Despite primary vaccination, infants under six months run a risk of infection with pertussis. Objective: To determine the impact of early postpartum maternal pertussis vaccination on protecting infants from the disease. Methods: All mothers (n=405) who gave birth to healthy term infants were ...  Read More

Original Article
5. CEA Plasmid as Therapeutic DNA Vaccination against Colorectal Cancer

Ziba Veisi Malekshahi; Nasser Hashemi Goradel; Mehdi Shakouri Khomartash; Amir Maleksabet; Maryam kadkhodazadeh; Gholam Ali Kardar; Babak Negahdari

Volume 16, Issue 3 , Summer 2019, Pages 235-245


  Background: Human colorectal cancer cells overexpress carcinoembryonic antigen (CEA). CEA is a glycoprotein which has shown to be a promising vaccine target for immunotherapy against colorectal cancer. Objective: To design a DNA vaccine harboring CEA antigen and evaluate its effect on inducing immunity ...  Read More

Original Article
6. Effects of CD133 Silencing on Survival and Migration of HT-29 Colorectal Cancer Cells

Morteza Akbari; Dariush Shanehbandi; Milad Asadi; Navid Shomali; Afsaneh Faraji; Vahid Khaze; Abbas Pakdel; Ahad Mokhtarzadeh; Ali Asghar Ebrahimi; Aliakbar Shabani; Behzad Baradaran

Volume 16, Issue 3 , Summer 2019, Pages 246-257


  Background: Colorectal cancer (CRC) is attributed as one of the most common malignancies worldwide. CD133 molecule, as a pentaspan transmembrane glycoprotein, confers stem cell-related characteristics, including self-renewal and multi-directional differentiation capability. CD133 plays important roles ...  Read More

Original Article
7. IgG Avidity Test for Ocular Toxoplasmosis Diagnosis at a Tertiary Center, Northeast of Iran

Elham Moghaddas; Seyedeh Maryam Hosseini; Karim Sharifi; Abdolrahim Rezai; Saman Soleimanpour; Mohammad Mobin Miri Moghaddam; Seyed Aliakbar Shamsian

Volume 16, Issue 3 , Summer 2019, Pages 258-264


  Background: The diagnostic methods which are used for acute ocular toxoplasmosis are very important; if the treatment is delayed, it sometimes leads to loss of vision. Fewstudies have been performed to evaluate serological tests used in the diagnosis of acute ocular toxoplasmosis. Objective: To evaluate ...  Read More

1. Airway Inflammatory Biomarker: Could It Tailor the Right Medications for the Right Asthmatic Patient?

Magdy Mohamed Zedan; Amal Mohamed Osman; Wafaa Nabil Laimon; Mohamed Magdy Zedan; Nermin Youssef Abo-elkheir; Ahmed Zaki

Volume 13, Issue 2 , Spring 2016, , Pages 70-88

  Asthma is a heterogeneous disease, in which asthmatic patients present with different clinical phenotypes, variable endotypes, and different response to asthma medicines. Thus, we are faced with an asthma paradox; asthma is diagnosed subjectively by clinical history and treated with biologically active ...  Read More

2. Correlation of Early and Late Ejection Fractions with CCL5 and CCL18 Levels in Acute Anterior Myocardial Infarction

Mahdi Sajedi Khania; Alireza Abdi Ardekan; Shahdad Khosropana; Mehrnoosh Doroudchi

Volume 13, Issue 2 , Spring 2016, , Pages 100-113

  Background: Acute Myocardial Infarction (AMI) is the leading cause of disability and death in Iran and many other countries. Objective: To investigate the prognostic value of CCL5 and CCL18 in patients with acute myocardial ischemia. Methods: In this cohort study we recruited and followed 50 patients ...  Read More

3. High Levels of IgA Antibodies to Helicobacter Pylori among Omani Women during Pregnancy and after Delivery

Mohammed Said Al-Balushi; Elias Anthony Said; Sidgi Syed Hasson; Juma Zaid Al-Busaidi; Iman Al-Reesi; Mohammed Idris; Wadha Al-Ghafri; Moza Al-Kalbani; Ali Abdullah Al-Jabri

Volume 13, Issue 2 , Spring 2016, , Pages 114-123

  Background: Helicobacter pylori (H. pylori), is a common infection in pregnant women accompanied by variations in the levels of the IgM, IgA and IgG antibody isotypes. The variations of anti-H. pylori antibodies during and after pregnancy, and the extent of protection they provide to the mother and the ...  Read More

4. Identification of the Rare, Four Repeat Allele of IL-4 Intron-3 VNTR Polymorphism in Indian Populations

Henu Kumar Verma; Aditya Nath Jha; Prafulla Kumar khodiar; Pradeep Kumar Patra; Lakkakula Venkata Kameswara Subrahmanya Bhaskar

Volume 13, Issue 2 , Spring 2016, , Pages 124-131

  Background: Cytokines are cell signaling molecules which upon release by cells facilitate the recruitment of immune-modulatory cells towards the sites of inflammation. Genetic variations in cytokine genes are shown to regulate their production and affect the risk of infectious as well as autoimmune diseases. ...  Read More

5. Efficiency and Impact of Positive and Negative Magnetic Separation on Monocyte Derived Dendritic Cell Generation

Marek Fol; Magdalena Kowalewicz-Kulbat; El ż bieta Ograczyk; Marcin W ł odarczyk; Krzysztof Krawczyk

Volume 13, Issue 2 , Spring 2016, , Pages 132-140

  Background: The immunomagnetic separation technique is the basis of monocyte isolation and further generation of monocyte-derived dendritic cells. Objective: To compare the efficiency of monocyte positive and negative separation, concentration of beads, and their impact on generated dendritic cells. ...  Read More

Shiraz Institute for Cancer Research

  Abbas Ghaderi, Ph.D.

Associate Editor:
  Mehrnoosh Doroudchi, Ph.D.

Assistant Editor:
  Morvarid Asadipour, M.Sc.

Print ISSN: 1735-1383

Online ISSN: 1735-367X


Shiraz University of medical Sciences

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