Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
1. Airway Inflammatory Biomarker: Could It Tailor the Right Medications for the Right Asthmatic Patient?

Magdy Mohamed Zedan; Amal Mohamed Osman; Wafaa Nabil Laimon; Mohamed Magdy Zedan; Nermin Youssef Abo-elkheir; Ahmed Zaki

Volume 13, Issue 2 , Spring 2016, , Pages 70-88

  Asthma is a heterogeneous disease, in which asthmatic patients present with different clinical phenotypes, variable endotypes, and different response to asthma medicines. Thus, we are faced with an asthma paradox; asthma is diagnosed subjectively by clinical history and treated with biologically active ...  Read More

2. Immunological Basis of Neurological Diseases

Mojtaba Zarei

Volume 1, Issue 1 , Spring 2004, , Pages 6-25

  Clinical neurology has been traditionally considered as an academic speciality in which the specialist regurgitates his/her knowledge of neurology without being able to do much for the patient. This attitude is no longer acceptable. Surge of information and discoveries in neurosciences within the last ...  Read More

3. Hemozoin Enhances Maturation of Murine Bone Marrow Derived Macrophages and Myeloid Dendritic Cells

Shahid Waseem; Kashif-Ur-Rehman -; Ramesh Kumar; Tariq Mahmood

Volume 13, Issue 1 , Winter 2016, , Pages 1-8

  Background: Falciparum malaria is a severe health burden worldwide. Antigen presenting cells are reported to be affected by erythrocytic stage of the parasite. Malarial hemozoin (HZ), a metabolite of malaria parasite, has adjuvant properties and may play a role in the induction of immune response against ...  Read More

4. Induction of T Regulatory Subsets from Naïve CD4+ T Cells after Exposure to Breast Cancer Adipose Derived Stem Cells

Mahboobeh Razmkhah; Nadieh Abedi; Ahmad Hosseini; Mohammad Taghi Imani; Abdol-Rasoul Talei; Abbas Ghaderi

Volume 12, Issue 1 , Winter 2015, , Pages 1-15

  Background: Adipose derived stem cells (ASCs) provoke the accumulation and expansion of regulatory T cells, leading to the modulation of immune responses in tumor microenvironment. Objective: To assess the effect of tumoral ASCs on the trend of regulatory T cells differentiation. Methods: Peripheral ...  Read More

5. Influence of 1 Alpha, 25-Dihydroxyvitamin D3 on T Helper 17 Cells and Related Cytokines in Systemic Lupus Erythematosus

Hadi Reihani; Maryam Rastin; Mahmoud Mahmoudi; Mohsen Ghoryani; Nafiseh Abdollahi; Nafiseh Sadat Tabasi; Shahrzad Zamani Taghizadeh Rabe; Maryam Sahebari

Volume 12, Issue 2 , Spring 2015, , Pages 82-93

  Background: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Emerging data suggests that T helper 17 (Th17) cells play a pathogenic role in SLE and the increased number of these cells correlates with disease activity. In recent years, 1α, 25-dihydroxyvitamin D3 (1,25VitD3) ...  Read More

6. Translational Insights on Lung Transplantation: Learning from Immunology

Mohamed Shehata Ali Mohamed

Volume 12, Issue 3 , Summer 2015, , Pages 156-165

  The introduction of ex vivo lung perfusion (EVLP) in the practice of lung transplantation has allowed the reconditioning of the marginal grafts and their conversion into transplantable grafts. In addition, EVLP can provide a platform for the application of various preventive measures to decrease the ...  Read More

7. Tumor Associated Mesenchymal Stromal Cells Show Higher Immunosuppressive and Angiogenic Properties Compared to Adipose Derived MSCs

Ladan Langroudi; Zuhair Muhammad Hassan; Masoud Soleimani; Seyed Mahmoud Hashemi

Volume 12, Issue 4 , Autumn 2015, , Pages 226-239

  Background: Differentiation, migratory properties and availability of Mesenchymal Stromal Cells (MSC) have become an important part of biomedical research. However, the functional heterogeneity of cells derived from different tissues has hampered providing definitive phenotypic markers for these cells. ...  Read More

8. Islet Amyloid Polypeptide is not a Target Antigen for CD8+ T-Cells in Type 2 Diabetes

Fathollah Kalantar; Mohammad Hossein Dabbaghmanesh; Emanuela Martinuzzi; Mohsen Moghadami; Zahra Amirghofran

Volume 11, Issue 1 , Winter 2014, , Pages 1-12

  Background: Type 2 diabetes (T2D) is a chronic metabolic disorder in which beta-cells are destroyed. The islet amyloid polypeptide (IAPP) produced by beta-cells has been reported to influence beta-cell destruction. Objective: To evaluate if IAPP can act as an autoantigen and therefore, to see if CD8 ...  Read More

9. CTL Responses to DCs Stimulated with Leishmania Antigens Detected by DCs Expressing Leishmania gp63

Hossein Rezvan; Ali Khodadadi; Selman Ali

Volume 11, Issue 2 , Spring 2014, , Pages 65-73

  Background: Leishmania is a pathogenic parasite which infects mononuclear cells in vertebrate hosts. Different strategies have been taken to develop immunity against Leishmania . DCs loaded with immunogenic antigen have resulted in different levels of Th1-type immune response and cytotoxic T lymphocytes ...  Read More

10. Regulatory T Cell Subtypes and TGF-β1 Gene Expression in Chronic Allograft Dysfunction

Sara Assadiasl; Pedram Ahmadpoor; Mohsen Nafar; Mahboob Lessan Pezeshki; Fateme Pourrezagholi; Mahmoud Parvin; Abtin Shahlaee; Adel Sepanjnia; Mohammad Hossein Nicknam; Aliakbar Amirzargar

Volume 11, Issue 3 , Summer 2014, , Pages 139-152

  Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic ...  Read More

11. Reference Values of Lymphocyte Sub-Populations in Healthy Human Immunodeficiency Virus-Negative Iranian Adults

Atefeh Kamallou; Mahbobeh Haji Abdolbaghi; Minoo Mohraz; Mernaz Rasolinejad; Ehsan Karbasi; Bita Ansaripour; Samaneh Soltani; Arezou Rezaei; Neda Khalili; Aliakbar Amirzargar

Volume 11, Issue 4 , Autumn 2014, , Pages 221-232

  Background: Lymphocyte subsets enumeration is considered prominent in the management of primary and acquired immunodeficiency disorders. Because of local variations due to race, age, gender, and environmental conditions on lymphocyte subsets, and to improve the accuracy of interpretation of laboratory ...  Read More

12. Role of Immunosuppression Minimization Protocols in Renal Transplantation

Nasrollah Ghahramani

Volume 1, Issue 2 , Summer 2004, , Pages 78-96

  The subject of transplant immunosuppression has generated significant interest in recent years. Excellent immunosuppression, advances in surgical technique, post-transplantation care, and infection control have resulted in excellent outcomes. There is widespread support for the notion that the fundamental ...  Read More

13. Association between HLA-DQB1*03:01 and Bullous Pemphigoid in Iranian Patients

Nafiseh Esmaili; Hossein Mortazavi; Sheyda Chams-Davatchi; Maryam Daneshpazhoooh; Maede Rayati Damavandi; Zeinab Aryanian; Ali Akbar Amirzargar

Volume 10, Issue 1 , Winter 2013, , Pages 1-9

  Background: A common Human Leukocyte Antigen (HLA) class II allele, DQβ1*03:01, seems to be associated with Bullous pemphigoid (BP) in Caucasians whereas previous studies in other ethnic groups showed other HLA class II alleles as genetic predisposing factors for BP. Objective: To investigate the ...  Read More

14. Indoleamine 2,3-Dioxygenase and Immunological Tolerance during Pregnancy

Amir Hassan Zarnani; Pouneh Dokouhaki; Mahmood Jeddi-Tehrani

Volume 1, Issue 3 , Autumn 2004, , Pages 143-153

  Indoleamine 2,3-dioxygenase (IDO), an enzyme involved in the catabolism of tryptophan, is expressed by a variety of cells and tissues such as macrophages, dendritic cells, cells of the endocrine system and by the placenta. IFN- γ is the main inducer of this enzyme. IDO acts as an important defense ...  Read More

15. Detection of IL-20R1 and IL-20R2 mRNA in C57BL/6 Mice Astroglial Cells and Brain Cortex Following LPS Stimulation

Bahareh Abd Nikfarjam; Massoumeh Ebtekar; Farzaneh Sabouni; Zahra Pourpak; Maryam Kheirandish

Volume 10, Issue 2 , Spring 2013, , Pages 62-69

  Background: Astrocytes, which comprise ~90% of overall brain mass, are involved in brain immunity. These cells represent the non-professional class of CNS-resident APCs and may promote or inhibit CNS inflammation depending on the cytokines they secrete. IL-10 family of cytokines and their receptors, ...  Read More

16. Monoclonal Antibodies as Therapeutic Agents: Advances and Challenges

Helmout Modjtahedi

Volume 2, Issue 1 , Winter 2005, , Pages 3-20

  Despite the major advances in conventional forms of treatment (i.e. surgical techniques, radiotherapy and chemotherapy) and improved survival rates, cancer is still the second leading cause of death in developing countries. One major limitation of cytotoxic drugs and radiation in the treatment of cancer ...  Read More

17. Construction and Expression of Hepatitis B Surface Antigen Escape Variants within the "a" Determinant by Site Directed Mutagenesis

Forough Golsaz Shirazi; Mohammad Mehdi Amiri; Hamed Mohammadi; Ali Ahmad Bayat; Azam Roohi; Jalal Khoshnoodi; Amir Hassan Zarnani; Mahmood Jeddi-Tehrani; Gholam Ali Kardar; Fazel Shokri

Volume 10, Issue 3 , Summer 2013, , Pages 127-138

  Background: The antibody response to hepatitis B surface antigen (HBsAg) controls hepatitis B virus infection. The "a" determinant of HBsAg is the most important target for protective antibody response, diagnosis and immunoprophylaxis. Mutations in this area may induce immune escape mutants and affect ...  Read More

18. IL-17 and IL-4 Producing CD8+ T Cells in Tumor Draining Lymph Nodes of Breast Cancer Patients: Positive Association with Tumor Progression

Zahra Faghih; Somayeh Rezaeifard; Akbar Safaei; Abbas Ghaderi; Nasrollah Erfani

Volume 10, Issue 4 , Autumn 2013, , Pages 193-204

  Background: CD8+ cytotoxic T lymphocytes have been recently divided based on their cytokine expression profile. Objective: To evaluate the percentages of CD8+ lymphocytes and their effector subsets including Tc1, Tc2 and Tc17 in the tumor draining lymph nodes (TDLNs) of patients with breast cancer. Methods: ...  Read More

19. The Jak-Stat Signaling Pathway of Interferons System: Snapshots

Masoumeh Varedi

Volume 2, Issue 2 , Spring 2005, , Pages 67-77

  Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological ...  Read More

20. Protein Profiling of the Secretome of FcεRI Activated RBL-2H3.1 Cells

Esmaeil Sadroddiny; Jafar Ai; Kathleen Carroll; Trong Khoa Pham; Phillip Wright; Ashutosh Pathak; Birgit Helm

Volume 9, Issue 1 , Winter 2012, , Pages 1-31

  Background: Secretory proteins of IgE receptor activated mast cells and basophils play a pivotal role in the generation of immediate and long term immune responses in allergy and type I hypersensitivity. Objective: The present study aims to generate a 2-D map and profile of proteins secreted from a high ...  Read More

21. Revisiting Beta 2 Glycoprotein I, the Major Autoantigen in the Antiphospholipid Syndrome

Soheila Rahgozar

Volume 9, Issue 2 , Spring 2012, , Pages 73-85

  Beta 2 glycoprotein I (β2GPI) is a single chain 50 kDa highly glycosylated glycoprotein at an approximate concentration of 4 μM in cells. The abundance of this protein in plasma and its high state of preservation indicate the important role of this protein in mammalian. In addition, β2GPI ...  Read More

22. Monocyte Expression of Toll-like Receptor-4 in Patients with Stable Angina Undergoing Percutanoeus Coronary Intervention

Bahador Bagheri; Bahram Sohrabi; Aliakbar Movassaghpur; Siminozar Mashayekhi; Afagh Garjani; Mehriar Shokri; Mohammad Noori; Alireza Garjani

Volume 9, Issue 3 , Summer 2012, , Pages 149-158

  Background: Toll like receptors (TLRs) are well recognized players in inflammatory conditions. Among them TLR-4 is involved in chronic inflammatory processes such as formation of atherosclerotic plaques. Objective: The present study was aimed to examine the effects of percutanoeus coronary intervention ...  Read More

23. An Endogenous Immune Adjuvant Released by Necrotic Cells for Enhancement of DNA Vaccine Potency

Rohollah Dorostkar; Taravat Bamdad; Masoud Parsania; Hassan Pouriayevali

Volume 9, Issue 4 , Autumn 2012, , Pages 215-225

  Background: Improving vaccine potency in the induction of a strong cell-mediated cytotoxicity can enhance the efficacy of vaccines. Necrotic cells and the supernatant of necrotic tumor cells are attractive adjuvants, on account of their ability to recruit antigen-presenting cells to the site of antigen ...  Read More

24. Expression of Chemokine Receptors on Th1/Th2 CD4+ Lymphocytes in Patients with Multiple Sclerosis

Alireza Andalib; Hassan Doulabi; Mohammadreza Najafi; Mehdi Tazhibi

Volume 8, Issue 1 , Winter 2011, , Pages 1-10

  Background: Th1 cells preferentially express CXCR3, CCR5 and CCR6, while CCR3 and CCR4 are predominantly expressed by Th2 cell subsets. Multiple Sclerosis (MS) is a Th1 cell-dependant chronic inflammatory disease of the central nervous system, and immunomudolatory cytokines could alter the chemokine ...  Read More

25. Strong Immune Responses Induced by a DNA Vaccine Containing HPV16 Truncated E7 C-terminal Linked to HSP70 Gene

Zahra Meshkat; Hoorieh Soleimanjahi; Hessam Mirshahabi; Mojtaba Meshkat; Maryam Kheiandish; Zuhair Mohammad Hassan

Volume 8, Issue 2 , Spring 2011, , Pages 65-75

  Background: Vaccines capable of controlling tumor virus based infections are found difficult to develop due to the consistence latent infection in the host. DNA vaccines are attractive tools for the development of HPV vaccines and inducing antigen-specific immunity owing to the stability, simplicity ...  Read More