Document Type: Original Article
Department of Cardiology,Shiraz University of Medical Sciences, Shiraz, Iran
Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Background: Acute Myocardial Infarction (AMI) is the leading cause of disability and death in Iran and many other countries.
Objective: To investigate the prognostic value of CCL5 and CCL18 in patients with acute myocardial ischemia. Methods: In this cohort study we recruited and followed 50 patients with acute anterior myocardial infarction (AAMI) for developing cardiovascular accidents in a 6-month period. CCL5 and CCL18 levels were measured on admission, at day 5 and at day 180 posthospitalization.
Results: CCL18 and CCL5 levels at day 180 were higher in patients with late (day 180) and early (day 5) LVEF less than 35% compared to those with higher LVEF (p=0.05 and p=0.042, respectively). There was a negative correlation between early and late LVEF and regional wall motion abnormalities (p=0.001 and p=0.002, respectively). There was also a trend of negative correlation between CCL18 levels at day 5 and LVEF levels at day 180 post-hospitalization (p=0.06).
Conclusion: CCL18 has a correlation with cardiac function in patients with AAMI and it might be considered as an indicator of poor LVEF in patients with AAMI.