Document Type: Short Paper

Authors

1 Department of Neurology and Isfahan Neurosciences Research Center

2 Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan

3 Immunology and Microbiology Department, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord

4 Department of Medical Sciences, Najafabad Branch, Islamic Azad University, Isfahan, Iran

5 Department of Immunology, School of Medicine, Isfahan University of Medical Sciences

Abstract

Background: Midkine (MK) is a heparin-binding growth factor with promoting effects in inflammatory responses through enhancing leukocytes migration.
Objective:
To study the correlation between MK serum levels and concentration of inflammatory cytokines in Multiple Sclerosis (MS) patients.
Methods:
We evaluated the MK level and its relationship with inflammatory cytokines (IL-17 and IL-23) and antiinflammatory ones (IL-10 and TGF-β) in multiple sclerosis (MS) patients. The serum concentrations of MK and cytokines were assessed by ELISA in 32 MS patients in comparison with 32 healthy subjects.
Results:
Our data showed that the MK concentration in MS patients is lower than healthy controls (341.15 ± 40.71 Pg/ml vs. 620.15 ± 98.61 Pg/ml, respectively, p=0.015). We also observed a significant decrease in IL-10, IL-23, and TGF-β cytokine levels in MS patients. There was a significant correlation between MK and IL-23 concentrations in our study (r = +0.829, p≤0.001).
Conclusion: These results confirm a role for MK in inflammatory reactions in MS.

Keywords