Document Type : Short Paper
Authors
- Vahid Shaygannejad 1
- Saeed Montazeri 2
- Azam Jamshidian 3
- Soheil Tahani 1, 4
- Marjan Gharagozloo 5
- Fereshteh Ashtari 1
- Sahar Vesal 1
- Seyed Javad Hasheminia 4
- Leila Dehghani 1, 4
1 Department of Neurology and Isfahan Neurosciences Research Center
2 Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan
3 Immunology and Microbiology Department, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord
4 Department of Medical Sciences, Najafabad Branch, Islamic Azad University, Isfahan, Iran
5 Department of Immunology, School of Medicine, Isfahan University of Medical Sciences
Abstract
Background: Midkine (MK) is a heparin-binding growth factor with promoting effects in inflammatory responses through enhancing leukocytes migration.
Objective: To study the correlation between MK serum levels and concentration of inflammatory cytokines in Multiple Sclerosis (MS) patients.
Methods: We evaluated the MK level and its relationship with inflammatory cytokines (IL-17 and IL-23) and antiinflammatory ones (IL-10 and TGF-β) in multiple sclerosis (MS) patients. The serum concentrations of MK and cytokines were assessed by ELISA in 32 MS patients in comparison with 32 healthy subjects.
Results: Our data showed that the MK concentration in MS patients is lower than healthy controls (341.15 ± 40.71 Pg/ml vs. 620.15 ± 98.61 Pg/ml, respectively, p=0.015). We also observed a significant decrease in IL-10, IL-23, and TGF-β cytokine levels in MS patients. There was a significant correlation between MK and IL-23 concentrations in our study (r = +0.829, p≤0.001).
Conclusion: These results confirm a role for MK in inflammatory reactions in MS.
Keywords
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