Document Type: Original Article
Mycology Research Centre, Faculty of Veterinary Medicine, Tehran University
Department of Biochemistry, Faculty of Veterinary Medicine, Tehran University
Department of Epidemiology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran
Background: Herbal medicines have been used since ancient times for treatment of a range of diseases and have represented stimulatory effects on the function of innate immunity.
Objective: To evaluate the effects of Zataria multiflora (Z. multiflora) on the function of innate immunity including phagocytic activity and TNF-α secretion in animal model.
Methods: Eight BALB/c mice were divided into two equal groups. In group A, Z. multiflora essence was injected intraperitoneally to the mice, in group B, distilled water was injected. Blood was obtained from 4 mice in each group, 4 and 7 days following injection. The amounts of phagocytosis (respiratory burst) and TNF-α secretion were assessed by chemiluminescence and ELISA method, respectively.
Results: Significant increase in phagocytosis and TNF-α secretion was observed in group A compared with the control group at days 4 and 7.
Conclusion: Z. multiflora essence can remarkably stimulate innate immunity function and it may be used to immunize individuals alone or in combination with other immunostimulatory agents.