1Mycology Research Centre, Faculty of Veterinary Medicine, Tehran University
2Department of Biochemistry, Faculty of Veterinary Medicine, Tehran University
3Department of Epidemiology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran
Background: Herbal medicines have been used since ancient times for treatment ofa range of diseases and have represented stimulatory effects on the function of innateimmunity. Objective: To evaluate the effects of Zataria multiflora (Z. multiflora) onthe function of innate immunity including phagocytic activity and TNF-α secretion inanimal model. Methods: Eight BALB/c mice were divided into two equal groups. Ingroup A, Z. multiflora essence was injected intraperitoneally to the mice, in group B,distilled water was injected. Blood was obtained from 4 mice in each group, 4 and 7days following injection. The amounts of phagocytosis (respiratory burst) and TNF-αsecretion were assessed by chemiluminescence and ELISA method, respectively. Results: Significant increase in phagocytosis and TNF-α secretion was observed ingroup A compared with the control group at days 4 and 7. Conclusion: Z. multiflora essence can remarkably stimulate innate immunity function and it may be used to immunize individuals alone or in combination with other immunostimulatory agents.