Prevalence of Antiphospholipid Antibodies in Syrian Patients with Thrombosis

Document Type: Original Article

Authors

1 Department of Internal Medicine

2 Department of Rheumatology

3 Department of Laboratory in Aleppo University, Aleppo, Syria

Abstract

Background: Antiphospholipid antibodies (aPL) are a heterogeneous family of anti-bodies associated with thrombosis and other complications.
Objective: To study the prevalence of aPL in patients with thrombosis at Aleppo University Hospitals, Syria.
Methods: One hundred and fifty-seven patients with venous and arterial thrombosis and 63 healthy controls were studied. Anticardiolipin antibodies (aCL) and Lupus antico-agulant (LA) were determined.
Results: Thirty-four out of 157 (21.7%) patients with thrombosis had some type of aPL. aPL was also found in four healthy subjects (4/63=6.3%). Eighteen patients (11.5%) were positive for LA, 20 (12.7%) for aCL anti-bodies and 4 (2.6%) were positive for more than one aPL. Patients without risk factors for thrombosis and having positive aPL were 23/34 (67.7%). Fourteen out of 78 (17.9%) patients with arterial thrombosis, and 20/79 (25.3%) with venous thrombosis were positive for at least one aPL.
Conclusion: Our study showed a significant preva-lence of aPL in patients with thrombosis. It seems that aPL is a risk factor for venous and arterial thrombosis, especially in patients with no conventional risk factors.

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