Evaluation of the miRNA-146a and miRNA-155 Expression Levels in Patients with Oral Lichen Planus

Document Type: Original Article

Authors

1 Dental Research Center, Department of Oral Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

2 Department of Immunology, Medical School, Hamadan University of Medical Sciences, Hamadan, Iran

3 Department of Genetic and Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

4 Department of Immunology, Medical School, Hamadan University of Medical Sciences, Hamadan, Iran

Abstract

Background: Oral Lichen Planus (OLP) is a chronic autoimmune disease that could be considered as a potential premalignant status. Objective: To evaluate the miRNA-146a and miRNA-155 expression levels in patients with oral Lichen planus lesions compared to healthy subjects with normal oral mucosa. Methods: Forty patients with oral lichen planus and 18 healthy age and gender-matched controls were recruited in this case-control study. Oral lichen planus was diagnosed clinically and pathologically. The expression levels of two miRNAs in peripheral blood samples were determined using commercial TaqMan MicroRNA Assays. Relative quantification of gene expression was calculated by the 2-ΔΔct method. Results: The expression levels of miRNA-146a and miRNA-155 in patients with oral Lichen planus were significantly higher than the of the healthy control group. Also, a direct but insignificant correlation was found between miRNA-155 and miRNA-146a expression levels among the patient group. Conclusion: Our findings indicate that miRNA-146a and miRNA-155 could be potential biomarkers for the immunopathogenesis of oral lichen planus.

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