Golmoghaddam, H., Farjadian, S., Khosropanah, S., Dehghani, P., Doroudchi, M. (2018). Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis. Iranian Journal of Immunology, 15(3), 197-206. doi: 10.22034/iji.2018.39389
Hossein Golmoghaddam; Shirin Farjadian; Shahdad Khosropanah; Pooyan Dehghani; Mehrnoosh Doroudchi. "Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis". Iranian Journal of Immunology, 15, 3, 2018, 197-206. doi: 10.22034/iji.2018.39389
Golmoghaddam, H., Farjadian, S., Khosropanah, S., Dehghani, P., Doroudchi, M. (2018). 'Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis', Iranian Journal of Immunology, 15(3), pp. 197-206. doi: 10.22034/iji.2018.39389
Golmoghaddam, H., Farjadian, S., Khosropanah, S., Dehghani, P., Doroudchi, M. Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis. Iranian Journal of Immunology, 2018; 15(3): 197-206. doi: 10.22034/iji.2018.39389
Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis
1Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Cardiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract
Background: Human leukocyte antigen (HLA) complex is a gene family involved in antigen presentation associated with protection or susceptibility to inflammatory, infectious and autoimmune diseases. Atherosclerosis is a chronic inflammatory disease in which HLA molecules play a role in the initiation and development of the disease through presentation of self or foreign antigens to T cells. Objective: To investigate the association of HLA-DRB1 alleles with atherosclerosis in a sample of southwestern Iranians. Methods: We performed an analytical cross-sectional study involving 96 patients with atherosclerosis and 72 controls. HLA-DRB1 genotyping was performed by PCR-SSP method. Results: We observed a significantly lower frequency of DRB1*01 in patients with coronary artery atherosclerosis than in controls (4.68% vs. 13.1, P=0.0052, OR=3.09, CI 95%: 1.35-7.05). However, this allele showed a positive association with high blood pressure (P=0.009) in patients. Furthermore, DRB1*16 allele was associated with hyperlipidemia (P=0.008) in patients. Conclusion: Our results demonstrated that DRB1*01 may be a protective allele against atherosclerosis in individuals who live in southwest of Iran. The mechanism of this protection needs further investigation.
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