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Iranian Journal of Immunology
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Volume Volume 15 (2018)
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Golmoghaddam, H., Farjadian, S., Khosropanah, S., Dehghani, P., Doroudchi, M. (2018). Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis. Iranian Journal of Immunology, 15(3), 197-206. doi: 10.22034/iji.2018.39389
Hossein Golmoghaddam; Shirin Farjadian; Shahdad Khosropanah; Pooyan Dehghani; Mehrnoosh Doroudchi. "Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis". Iranian Journal of Immunology, 15, 3, 2018, 197-206. doi: 10.22034/iji.2018.39389
Golmoghaddam, H., Farjadian, S., Khosropanah, S., Dehghani, P., Doroudchi, M. (2018). 'Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis', Iranian Journal of Immunology, 15(3), pp. 197-206. doi: 10.22034/iji.2018.39389
Golmoghaddam, H., Farjadian, S., Khosropanah, S., Dehghani, P., Doroudchi, M. Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis. Iranian Journal of Immunology, 2018; 15(3): 197-206. doi: 10.22034/iji.2018.39389

Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis

Article 4, Volume 15, Issue 3, Summer 2018, Page 197-206  XML PDF (167.95 K)
Document Type: Original Article
DOI: 10.22034/iji.2018.39389
Authors
Hossein Golmoghaddam1; Shirin Farjadian1; Shahdad Khosropanah2; Pooyan Dehghani2; Mehrnoosh Doroudchi email 1
1Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Cardiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract
Background: Human leukocyte antigen (HLA) complex is a gene family involved in antigen presentation associated with protection or susceptibility to inflammatory, infectious and autoimmune diseases. Atherosclerosis is a chronic inflammatory disease in which HLA molecules play a role in the initiation and development of the disease through presentation of self or foreign antigens to T cells. Objective: To investigate the association of HLA-DRB1 alleles with atherosclerosis in a sample of southwestern Iranians. Methods: We performed an analytical cross-sectional study involving 96 patients with atherosclerosis and 72 controls. HLA-DRB1 genotyping was performed by PCR-SSP method. Results: We observed a significantly lower frequency of DRB1*01 in patients with coronary artery atherosclerosis than in controls (4.68% vs. 13.1, P=0.0052, OR=3.09, CI 95%: 1.35-7.05). However, this allele showed a positive association with high blood pressure (P=0.009) in patients. Furthermore, DRB1*16 allele was associated with hyperlipidemia (P=0.008) in patients. Conclusion: Our results demonstrated that DRB1*01 may be a protective allele against atherosclerosis in individuals who live in southwest of Iran. The mechanism of this protection needs further investigation.
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