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CEA Plasmid as Therapeutic DNA Vaccination against Colorectal Cancer

Ziba Veisi Malekshahi; Nasser Hashemi Goradel; Mehdi Shakouri Khomartash; Amir Maleksabet; Maryam kadkhodazadeh; Gholam Ali Kardar; Babak Negahdari

Volume 16, Issue 3 , September 2019, , Pages 235-245

https://doi.org/10.22034/iji.2019.80274

Abstract
  Background: Human colorectal cancer cells overexpress carcinoembryonic antigen (CEA). CEA is a glycoprotein which has shown to be a promising vaccine target for immunotherapy against colorectal cancer. Objective: To design a DNA vaccine harboring CEA antigen and evaluate its effect on inducing immunity ...  Read More