Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)

Aim and scope:
The Iranian Journal of Immunology (I.J.I) is an internationally disseminated peer-reviewed publication and publishes a broad range of experimental and theoretical studies concerned with all aspects of immunology.

Types of papers accepted:
The Journal will welcome original and review articles on basic and clinical Immunology, Immunogenetics, Transplantation Immunology, Immunohematology, Cancer Immunology, and Allergy. The Journal will also welcome short papers and letters to the Editor.

Iranian Journal of Immunology is indexed in the following indexing systems: 

  • Web of Science (ISI)
  • EMNursing
  • Cambridge Scientific Abstracts
  • Chemical Abstracts
  • Global Health
  • Index Medicus for Eastern Mediterranean Region (IMEMR)

IJI, is an official publication of the Iranian Society for Immunology and Allergy (ISIA), which is published by Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences (SUMS), Shiraz, Iran.

Review Article
1. DNA Based Vaccines against Mycobacterium Tuberculosis: Recent Progress in Vaccine Development and Delivery System

Ahmad Mobed

Volume 17, Issue 4 , Autumn 2020, Pages 255-274


  Tuberculosis (TB) is believed to be one of the leading causes of death in the world; nevertheless, Bacillus Calmette-Guérin (BCG) is the solitary vaccine utilized to prevent TB. Despite the protective effect of this vaccine in children, its efficiency remains under question in adults. We conducted ...  Read More

Original Article
2. Interleukin-27 Suppresses T Helper-17 Inflammation in Allergic Rhinitis

Hong Ouyang; Jie Cheng; Jingdong Du; Huiyun Gan; Zheng Lu

Volume 17, Issue 4 , Autumn 2020, Pages 275-282


  Background: T helper 17 (Th17) cells and the related cytokines, interleukin (IL)- 17 and IL-23, were proved to play pivotal roles during the development of allergic rhinitis (AR). IL-27, an anti-inflammatory cytokine, has been reported to promote the production of IL-12R and induce Th1 cell responses. ...  Read More

Original Article
3. Clinical Efficacy of Vitamin D3 Adjuvant Therapy in Allergic Rhinitis: A Randomized Controlled Trial

Xiaoling Liu; Xiaojia Liu; Yu Ren; Hongxin Yang; Xiaolei Sun; Haiyun Huang

Volume 17, Issue 4 , Autumn 2020, Pages 283-291


  Background: Vitamin D supplementation has been proven to be effective in the treatment of allergic rhinitis (AR). Objective: We conducted the present study to explore the role and efficacy of vitamin D adjuvant therapy for the treatment of inflammation in patients with AR. Methods: Out of 127 patients ...  Read More

Original Article
4. Identification of Functional Fragments in gMYL6 and the Mechanism of Improving NK Cell-Mediated Cytotoxicity

Yuying Ji; Rui Cao; Guangxin Lv; Yuanyuan Jin; Jing Chen

Volume 17, Issue 4 , Autumn 2020, Pages 292-302


  Background: In a previous study, the unrecognized role of gMYL6 in the up-regulation of human NK cells development and cytotoxicity was reported. Objective: To further elucidate the mechanism of action of small recombinant fragments of gMYL6 enhancing the NK cells activity. Methods: Mononuclear cells ...  Read More

Original Article
5. Glucocorticoids Regulate the Activation of Neutrophils and Inhibit the Formation of Pulmonary Embolism

Zhefeng Meng; Keyu Sun; Zichen Xie; Yang Li; Yanyan Li; Jianfeng Song

Volume 17, Issue 4 , Autumn 2020, Pages 303-312


  Background: There is a close relationship between neutrophil extracellular traps (NETs) and venous thromboembolism (VTE). The regulatory role and mechanism of glucocorticoids (GC) in the formation of NETs are unclear. Objective: This study was conducted to assess the effect of GC on the formation ...  Read More

Original Article
6. Toll-Like Receptor (TLR)-9 rs352140 Polymorphism is an Immunopathology Protective Factor in Parkinson's Disease in the Northern Iranian Population

Niloufar Sadat Miri; Payam Saadat; Abbas Azadmehr; morteza oladnabi; Abdolreza Daraei

Volume 17, Issue 4 , Autumn 2020, Pages 313-323


  Background: Neuroinflammation and immunopathology in Parkinson's disease (PD) are believed to be associated with genetic and environmental factors. Objective: We conducted the current study to evaluate the Toll-like receptors (TLR4 and TLR9) genes polymorphism in patients with Parkinson's disease ...  Read More

Original Article
7. Serum Level of Soluble Lymphocyte-Activation Gene 3 Is Increased in Patients with Rheumatoid Arthritis

Nayyereh Saadati; Mandana khodashahi; Zahra Rezaieyazdi; Maryam Sahebari; Zeinab Saremi; Saeed Mohammadian Haftcheshmeh; Houshang Rafatpanah; Maryam Salehi

Volume 17, Issue 4 , Autumn 2020, Pages 324-332


  Background: Rheumatoid arthritis (RA) is described as a systemic and chronic autoimmune disease characterized by inflammatory polyarthritis. Lymphocyte-activation gene 3 (LAG3) is a membrane glycoprotein expressed on activated, exhausted, and regulatory T cells. LAG3 plays a major role in the function ...  Read More

Case Report
8. Identical Twins with a Mutation in the STK4 Gene Showing Clinical Manifestations of the Mutation at Different Ages: A Case Report

Farhad Abolnezhadian; Sara Iranparast; Fatemeh Ahmadpour

Volume 17, Issue 4 , Autumn 2020, Pages 333-340


  Combined immunodeficiencies (CIDs) are a heterogeneous group of disorders characterized by various gene mutations. The mutations in the STK4 (Serine Threonine Kinase 4) gene, which has a role in the regulation of apoptosis and proliferation, can be a cause of immunodeficiency. In the current paper, we ...  Read More

1. Airway Inflammatory Biomarker: Could It Tailor the Right Medications for the Right Asthmatic Patient?

Magdy Mohamed Zedan; Amal Mohamed Osman; Wafaa Nabil Laimon; Mohamed Magdy Zedan; Nermin Youssef Abo-elkheir; Ahmed Zaki

Volume 13, Issue 2 , Spring 2016, , Pages 70-88

  Asthma is a heterogeneous disease, in which asthmatic patients present with different clinical phenotypes, variable endotypes, and different response to asthma medicines. Thus, we are faced with an asthma paradox; asthma is diagnosed subjectively by clinical history and treated with biologically active ...  Read More

2. Efficiency and Impact of Positive and Negative Magnetic Separation on Monocyte Derived Dendritic Cell Generation

Marek Fol; Magdalena Kowalewicz-Kulbat; El ż bieta Ograczyk; Marcin W ł odarczyk; Krzysztof Krawczyk

Volume 13, Issue 2 , Spring 2016, , Pages 132-140

  Background: The immunomagnetic separation technique is the basis of monocyte isolation and further generation of monocyte-derived dendritic cells. Objective: To compare the efficiency of monocyte positive and negative separation, concentration of beads, and their impact on generated dendritic cells. ...  Read More

3. High Levels of IgA Antibodies to Helicobacter Pylori among Omani Women during Pregnancy and after Delivery

Mohammed Said Al-Balushi; Elias Anthony Said; Sidgi Syed Hasson; Juma Zaid Al-Busaidi; Iman Al-Reesi; Mohammed Idris; Wadha Al-Ghafri; Moza Al-Kalbani; Ali Abdullah Al-Jabri

Volume 13, Issue 2 , Spring 2016, , Pages 114-123

  Background: Helicobacter pylori (H. pylori), is a common infection in pregnant women accompanied by variations in the levels of the IgM, IgA and IgG antibody isotypes. The variations of anti-H. pylori antibodies during and after pregnancy, and the extent of protection they provide to the mother and the ...  Read More

4. Correlation of Early and Late Ejection Fractions with CCL5 and CCL18 Levels in Acute Anterior Myocardial Infarction

Mahdi Sajedi Khania; Alireza Abdi Ardekan; Shahdad Khosropana; Mehrnoosh Doroudchi

Volume 13, Issue 2 , Spring 2016, , Pages 100-113

  Background: Acute Myocardial Infarction (AMI) is the leading cause of disability and death in Iran and many other countries. Objective: To investigate the prognostic value of CCL5 and CCL18 in patients with acute myocardial ischemia. Methods: In this cohort study we recruited and followed 50 patients ...  Read More

5. Pathogenesis of Atopic Dermatitis: Current Paradigm

Masutaka Furue; Dugarmaa Ulzii; Yen Vu; Gaku Tsuji; Makiko Kido-Nakahara; Takeshi Nakahara

Volume 16, Issue 2 , Spring 2019, , Pages 97-107


  Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles ...  Read More

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