Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)

Aim and scope:
The Iranian Journal of Immunology (I.J.I) is an internationally disseminated peer-reviewed publication and publishes a broad range of experimental and theoretical studies concerned with all aspects of immunology.

Types of papers accepted:
The Journal will welcome original and review articles on basic and clinical Immunology, Immunogenetics, Transplantation Immunology, Immunohematology, Cancer Immunology, and Allergy. The Journal will also welcome short papers and letters to the Editor.

Iranian Journal of Immunology is indexed in the following indexing systems: 

  • Web of Science (ISI)
  • EMNursing
  • Cambridge Scientific Abstracts
  • Chemical Abstracts
  • Global Health
  • Index Medicus for Eastern Mediterranean Region (IMEMR)

IJI, is an official publication of the Iranian Society for Immunology and Allergy (ISIA), which is published by Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences (SUMS), Shiraz, Iran.

Original Article
1. Identification of the Optimal Pattern of the Injection and Dosage of DC Immunotherapy Using the Mathematical Models Based on Ordinary Differential Equations

Bahareh Zand; Samaneh Arab; Nasim Kheshtchin; Abazar Arabameri; Mahboubeh Ashourpour; Davoud Asemani; Ehsan Sharif-Paghaleh; Farshid Noorbakhsh; Jamshid Hadjati

Volume 19, Issue 1 , Winter 2022, Pages 1-17


  Background: Mathematical modeling offers the possibility to select the optimal dose of a drug or vaccine. Considerable evidence show that many bacterial components can activate dendritic cells (DCs). Our previous report showed that multiple doses of DCs matured with Listeria monocytogenes led to tumor ...  Read More

Original Article
2. Follicular Helper T Cells in Pulmonary Tuberculosis: A Retrospective Study

Haibai Sun; Jiaqing Liu; Ranran Feng; Chunyan Wang; Yuming Li; Xiao Wang

Volume 19, Issue 1 , Winter 2022, Pages 18-26


  Background: Follicular helper T lymphocyte (Tfh) promotes antibody production by B lymphocytes in various diseases, including Pulmonary Tuberculosis (PTB). Objective: To explore the potential role of Tfh cells and assess the expression level of PD-1, and IL-21 in PTB. Methods: 54 newly diagnosed ...  Read More

Original Article
3. Prenatal exposure of rats to staphylococcal enterotoxin B alters the expression of Th1 and Th2 cytokines via decreased methylation in the spleen of adult but not neonatal offspring

Jing Sun; Jiabao Zhao; Chao Sun; Yu ting Zhu; Ping Zhou; Shu xian Gao; Ying-Ao Fan; Hao-Yuan Jiang; Qing-Wei Zheng; Jun-Chang Guan

Volume 19, Issue 1 , Winter 2022, Pages 27-36


  Background: The methylation of IFN-γ and IL-4 genes is regarded as an epigenetic regulation that maintains the Th1 or Th2 phenotype. Objective: To explore the influence of prenatal administration of the staphylococcal enterotoxin B (SEB) in pregnant rats, on the IFN-γ or IL-4 expression ...  Read More

Original Article
4. LPS Activated Macrophages Induced Hepatocyte Pyroptosis via P2X7R Activation of NLRP3 in Mice

Lidan Luo; Yuan Fang; Qi Yuan; Jinmao Liao; Zheng Zhang

Volume 19, Issue 1 , Winter 2022, Pages 37-48


  Background: Pyroptosis is a programmed cell death related to caspase-1, accompanied by the secretion of pro-inflammatory cytokines. Objectives: To explore the effects of LPS on the P2X7R/NLRP3 pathway in macrophages, and hepatocytes pyroptosis in mice. Methods: LPS was used to establish an animal ...  Read More

Original Article
5. High Neutrophil-lymphocyte Ratio Predicts Serious Renal Insufficiency in Patients with Lupus Nephritis

Dijiao Tang; Qi Tang; Long Zhang; Hongxu Wang

Volume 19, Issue 1 , Winter 2022, Pages 49-57


  Background: Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE).The neutrophil to lymphocyte ratio (NLR) is a promising predictor and prognostic factor. An increased NLR is associated with a poor prognosis of several inflammatory diseases. Objective: ...  Read More

Original Article
6. Treatment by PI3K/mTOR Inhibitor BEZ235 Combined with TLR-7/8 Agonist Interfere with Immune Evasion Mechanisms of WEHI-3 Mouse Leukemia Cells

Saeid Taghiloo; Abolghasem Ajami; Reza Alizadeh-Navaei; Ehsan Zaboli; Hossein Asgarian-Omran

Volume 19, Issue 1 , Winter 2022, Pages 58-70


  Background: Several PI3K/Akt/mTOR pathway inhibitors and TLR agonists induce tumor cell death. However, the mechanisms of these therapeutic approaches in acute myeloid leukemia (AML) cells are still unknown. Objectives: To investigate the effects of BEZ235, as a dual inhibitor of PI3K and mTOR pathways, ...  Read More

Original Article
7. Immunomodulatory Effects of Omega-3 Fatty Acids in Patients with Differentiated Thyroid Cancer Before or After Radioiodine Ablation

Zeinab Amirkhani; Mehrosadat Alavi; Mehdi Kalani; Ali Alavianmehr; Shirin Farjadian

Volume 19, Issue 1 , Winter 2022, Pages 71-90


  Background: Thyroid cancer and radioactive iodine (RAI) ablation for postsurgical management may lead to uncontrolled inflammation. Objective: This study was intended to assess the prophylactic and therapeutic immunomodulatory effects of omega-3 fatty acids in patients with differentiated thyroid ...  Read More

Review Article
8. Effects of Interleukin-10 -1082G/A and -592C/A Gene Polymorphisms on the Risk of Human Immunodeficiency Virus-1 Infection: An Updated Meta-analysis

Zhi-Hui Wang; Yue Wu; Zi-Wei Dai; Yuan-Yuan Dong; Bin Wang

Volume 19, Issue 1 , Winter 2022, Pages 91-101


  This paper has aimed to review the available evidence on the association between Interleukin (IL) -10 -1082G/A, -592C/A gene polymorphisms and the risk of human immunodeficiency virus-1(HIV-1) infection. The data of PubMed updated in May 2021 were retrieved. The HIV infection risks were estimated in ...  Read More

Original Article
9. Cytokine Gene Polymorphisms in Chinese Children with Idiopathic Nephrotic Syndrome

Wei Li; Lin Li; Lin He; Yun Du; Hai-Dong Fu; Zhao-Yang Peng; Wen-Qing Xiang; Jian-Hua Mao

Volume 19, Issue 1 , Winter 2022, Pages 102-109


  Background: Cytokines play a role in the progression of idiopathic-nephrotic syndrome (INS). Objectives: To investigate the association of different cytokine genes polymorphisms with INS incidence and response to steroid therapy in Chinese children. Methods: 182 children with INS and 100 healthy ...  Read More

Case Report
10. Relapsing Polychondritis Associated with Miscellaneous Ocular Symptoms and Increased IgA: a Case Report

Yu Zhang; Li Zhang; Zhen zhen Wu; Jianping Tang; Xuan Wang

Volume 19, Issue 1 , Winter 2022, Pages 110-114


  A male patient had suffered miscellaneous ocular symptoms for 20 years with auricular dysmorphosis and was diagnosed with Relapsing Polychondritis (RP) in the ear, nose, joints, and costal cartilage. The patient lost his vision owing to recurrent ocular symptoms for decades. He presented an increased ...  Read More

Case Report
11. Case Report of China/Tianjin's First Novel Coronavirus Variant Omicron

Haibai Sun; Hongjie Li; Shuping Huang; Lixia Shi; Zhiyan Xing; Jun Shen

Volume 19, Issue 1 , Winter 2022, Pages 115-120


  COVID-19 is a new acute respiratory infectious disease caused by a novel Coronavirus (2019-COV-2) infection. On November 26, 2021, the World Health Organization announced a new 2019-COV-2 variant strain Omicron (B.1.1.529). Omicron's emergence added further uncertainty to the outbreak. Here we report ...  Read More

1. The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis

Min Lin; Jin Huang; Wei-Chang Chen; Zhi-Ning Fan; Xihu Qin

Volume 17, Issue 1 , Winter 2020, , Pages 52-63


  Background: Tim-3 has been considered as an ideal target for the immunotherapy of inflammation, but it is unclear whether Tim-3 also plays an important role in acute pancreatitis (AP), as well. Objective: To identify the immunomodulatory effects and mechanisms of Tim-3 action in the early stages of severe ...  Read More

2. Expression of Human Cytokine Genes Associated with Chronic Hepatitis B Disease Progression
Volume 14, Issue 4 , Autumn 2017, , Pages 281-292

  Background: Hepatitis viruses are non-cytopathic viruses that lead to the infection and pathogenesis of liver diseases as a result of immunologically mediated event. Objective: To investigate the expression of human inflammatory cytokines in chronic hepatitis B patients according to the severity of the ...  Read More

3. Pathogenesis of Atopic Dermatitis: Current Paradigm

Masutaka Furue; Dugarmaa Ulzii; Yen Vu; Gaku Tsuji; Makiko Kido-Nakahara; Takeshi Nakahara

Volume 16, Issue 2 , Spring 2019, , Pages 97-107


  Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles ...  Read More

4. Airway Inflammatory Biomarker: Could It Tailor the Right Medications for the Right Asthmatic Patient?

Magdy Mohamed Zedan; Amal Mohamed Osman; Wafaa Nabil Laimon; Mohamed Magdy Zedan; Nermin Youssef Abo-elkheir; Ahmed Zaki

Volume 13, Issue 2 , Spring 2016, , Pages 70-88

  Asthma is a heterogeneous disease, in which asthmatic patients present with different clinical phenotypes, variable endotypes, and different response to asthma medicines. Thus, we are faced with an asthma paradox; asthma is diagnosed subjectively by clinical history and treated with biologically active ...  Read More

Shiraz Institute for Cancer Research

  Abbas Ghaderi, Distinguished Professor of Immunology

Associate Editor:
  Fereshteh Mehdipour, MD, Ph.D.

Editorial Manager:
  Mahyar Malekzadeh, Ph.D. Student

Executive Assistant:
  Hamid Ghaderi, DDS

Print ISSN: 1735-1383

Online ISSN: 1735-367X

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