Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)

Aim and scope:
The Iranian Journal of Immunology (I.J.I) is an internationally disseminated peer-reviewed publication and publishes a broad range of experimental and theoretical studies concerned with all aspects of immunology.

Types of papers accepted:
The Journal will welcome original and review articles on basic and clinical Immunology, Immunogenetics, Transplantation Immunology, Immunohematology, Cancer Immunology, and Allergy. The Journal will also welcome short papers and letters to the Editor.

Iranian Journal of Immunology is indexed in the following indexing systems: 

  • Web of Science (ISI)
  • EMNursing
  • Cambridge Scientific Abstracts
  • Chemical Abstracts
  • Global Health
  • Index Medicus for Eastern Mediterranean Region (IMEMR)

IJI, is an official publication of the Iranian Society for Immunology and Allergy (ISIA), which is published by Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences (SUMS), Shiraz, Iran.

Review Article
Behaviors of Human T cells in SARS-CoV-2 Infection: Lessons and Tips

Ali Shams; Sahar Khosravi; Aysan Zareiye; Yeganeh Lalehzari; Reyhane Nematollahi; Solmaz Basti

Volume 20, Issue 4 , December 2023, Pages 382-399


  Cell-mediated immunity (CMI) is crucial in controlling the highly aggressive and progressive SARS-CoV-2 infection. Despite extensive researches on severe COVID-19 infection, the etiology and/or mechanisms of lymphopenia, decreased T cell-mediated responses in patients, cytokine release storms (CRS), ...  Read More

Original Article
Antibody Production after COVID-19 Vaccination in Patients with Inborn Errors of Immunity

Maryam Nourizadeh; Elham Feizabadi; Milad Mirmoghtadaei; Ashraf Mohammadi; Mohammad Reza Fazlollahi; Leila Moradi; Zahra Pourpak

Volume 20, Issue 4 , December 2023, Pages 400-409


  Background: Few studies have evaluated COVID-19 vaccine efficacy in patients with inborn errors of immunity (IEI).Objective: To evaluate the levels of antibody (Ab) production and function after COVID-19 vaccination in IEI patients with phagocytic, complement, and Ab deficiencies and their comparison ...  Read More

Original Article
Harnessing the Power of CAR-NK Cells: A Promising Off-the-Shelf Therapeutic Strategy for CD38-Positive Malignancies

Maryam Asadi; Razie Kiani; Vahid Razban; Seyed Nooreddin Faraji; Amirhossein Ahmadi; Jafar Fallahi; Amin Ramezani; Nasrollah Erfani

Volume 20, Issue 4 , December 2023, Pages 410-426


  Background: CD38 is highly expressed on multiple myeloma (MM) cells and has been successfully targeted by different target therapy methods. This molecule is a critical prognostic marker in both diffuse large B-cell lymphoma and chronic lymphocytic leukemia.Objective: We have designed and generated an ...  Read More

Original Article
Relationship between TIM3 Expression on Peripheral T Lymphocytes and Post-Stroke Depression

Qifen Mao; Peng Zhang; Weicui Qi; Yueping Xia; Tingting Chen; Xiaofang Li; Songquan Xu; Zhiqiang Zhong; Zuifei Shangguan

Volume 20, Issue 4 , December 2023, Pages 427-437


  Background: T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is a regulatory molecule expressed on a variety of cell types, including CD3+ T cells. Few studies have been conducted to look into the correlation between TIM3 expression on peripheral T lymphocytes and post-stroke depression ...  Read More

Original Article
Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T cells in Acute Leukemia

Maryam Mohammadi; Hossein Asgarian-Omran; Behnam Najafi; Ahmad Najafi; Reza Valadan; Hossein Karami; Mohammad Naderisoraki; Maryam Alizadeforutan; Ramin Shekarriz; Mohsen Tehrani

Volume 20, Issue 4 , December 2023, Pages 438-445


  Background: Thymocyte selection-associated high mobility group box protein (TOX) and members of the nuclear receptor 4A (NR4A) are known as transcription factors involved in T cell exhaustion.Objective: To evaluate the mRNA expression of TOX and NR4A1-3 in CD8+ T cells in acute leukemia.Methods: Blood ...  Read More

Original Article
Human Umbilical Cord Mesenchymal Stem Cells and their Extracellular Vesicles Modulate Pro- and Anti-inflammatory Cytokines in Ligature-induced Periodontitis

Xixi Wang

Volume 20, Issue 4 , December 2023, Pages 446-455


  Background: Periodontitis is a chronic inflammatory condition that affects the tissues supporting the teeth, ultimately leading to tooth loss. Mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) play a crucial role in periodontitis by modulating the activities of gum cells and the immune ...  Read More

Original Article
High-free Fatty Acid Treatment Induced Anti-inflammatory Changes in a Natural Killer (NK) Cell Line

Hong Wu; Yanqi Fu; Yuhuan Jiang; Yali Liu; Zhibin Cheng; Yanting Shao; Yijun Nie

Volume 20, Issue 4 , December 2023, Pages 456-465


  Background: Natural killer (NK) cells play a role in the pathogenesis of various metabolic diseases related to obesity. While our initial findings have indicated a potential involvement of NK cells in the pathogenesis of type 2 diabetes mellitus, the precise mechanism underlying NK cell-mediated development ...  Read More

Case Report
Rescue of HLH with T and B Lymphocyte Involvement Due to Epstein-Barr Virus by PD-1 Inhibitor/Ruxolitinib and Rituximab Combination Regimens: A Case Report

Miao Zhu; Jun Zhang; Qingqing Shi; Xing Sun; Haibo Wang; Mei Sun; Yanqing Liu

Volume 20, Issue 4 , December 2023, Pages 466-472


  Hemophagocytic lymphohistiocytosis (HLH) is a fatal clinical syndrome. The most common cause of secondary HLH is Epstein-Barr virus (EBV) infection. EBV-HLH is a common clinical disease with high mortality, easy relapse, and poor prognosis. Therefore, treating EBV-HLH with T and B lymphocyte involvement ...  Read More

The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis

Min Lin; Jin Huang; Wei-Chang Chen; Zhi-Ning Fan; Xihu Qin

Volume 17, Issue 1 , March 2020, , Pages 52-63


  Background: Tim-3 has been considered as an ideal target for the immunotherapy of inflammation, but it is unclear whether Tim-3 also plays an important role in acute pancreatitis (AP), as well. Objective: To identify the immunomodulatory effects and mechanisms of Tim-3 action in the early stages of severe ...  Read More

Expression of Human Cytokine Genes Associated with Chronic Hepatitis B Disease Progression
Volume 14, Issue 4 , December 2017, , Pages 281-292

  Background: Hepatitis viruses are non-cytopathic viruses that lead to the infection and pathogenesis of liver diseases as a result of immunologically mediated event. Objective: To investigate the expression of human inflammatory cytokines in chronic hepatitis B patients according to the severity of the ...  Read More

Pathogenesis of Atopic Dermatitis: Current Paradigm

Masutaka Furue; Dugarmaa Ulzii; Yen Vu; Gaku Tsuji; Makiko Kido-Nakahara; Takeshi Nakahara

Volume 16, Issue 2 , June 2019, , Pages 97-107


  Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles ...  Read More

Role of Interleukin-37 in Inflammatory and Autoimmune Diseases

Xiaoying Wang; Keye Xu; Sisi Chen; Yan Li; Mingcai Li

Volume 15, Issue 3 , September 2018, , Pages 165-174


  Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 suppression. IL-37 also translocates to the cell ...  Read More

Original Article
The Ratio of Peripheral Blood Natural Killer Cells is not a Solid Surrogate Immune Index in Unexplained Recurrent Miscarriage

Niwei Yan; Pingyin Lee; Huiying Jie; Canquan Zhou; Yuan Yuan

Articles in Press, Accepted Manuscript, Available Online from 13 January 2024


  Background: Immunotherapies targeting peripheral natural killer (pbNK) cells in unexplained recurrent miscarriage (uRM) remain controversial. We hypothesized that the change in pbNK cell count might be a result of innate immune responses rather than a cause.Objective: To explore whether the pbNK count ...  Read More

Original Article
Intervention with ICOSL Antibodies Alleviates Inflammatory Infiltrations in Mice with Neutrophilic Asthma

Heting Dong; Yinying Ren; Yiyi Song; Wei Ji; Yongdong Yan; Canhong Zhu; Li Huang; Meijuan Wang; Wenjing Gu; Xinxing Zhang; Huiming Sun; Chuangli Hao; Zhengrong Chen

Articles in Press, Accepted Manuscript, Available Online from 31 January 2024


  Background: Neutrophilic asthma is characterized by the predominant infiltration of neutrophils in airway inflammation.Objective: To explore the therapeutic potential of an antibody against the inducible T cell co-stimulator ligand (ICOSL) in a mouse model of neutrophilic asthma.Methods: Female BALB/c ...  Read More

Original Article
Sulforaphane Regulates Macrophage M1/M2 Polarization to Attenuate Macrophage-induced Caco-2 Cell Injury in an Inflammatory Environment

Ting Yi; Zhiyin Liu; Haokun Jia; Qiongzhi Liu; Jianjiao Peng

Articles in Press, Accepted Manuscript, Available Online from 05 February 2024


  Background: The imbalance between M1 and M2 macrophage activation is closely associated with the pathogenesis of inflammatory bowel diseases (IBDs). Sulforaphane (SFN) plays an important role in the treatment of inflammatory diseases.Objective: To investigate the effect of SFN on macrophage polarization ...  Read More

Original Article
Abnormal Changes in IL-13 and IL-17A Serum Levels in Children with Adenovirus Pneumonia and their Diagnostic Value

Jianbo Jiang; Lili Sun; Meixia Huang

Articles in Press, Accepted Manuscript, Available Online from 13 February 2024


  Background: Human adenovirus (HAdV) is an enveloped icosahedral DNA virus. HAdV infection can lead to immune system damage, resulting in decreased numbers and compromised function of T cells and B cells. It can also cause an imbalanced Th1/Th2 ratio and dysregulation of pro-inflammatory and anti-inflammatory ...  Read More

Original Article
MicroRNA-150 Deletion Reduces the Occurrence and Severity of Rheumatoid Arthritis by Inhibiting IL-17


Articles in Press, Accepted Manuscript, Available Online from 13 February 2024


  Background: Understanding the effects of epigenetic factors on the pathogenesis of rheumatoid arthritis (RA) is important for the early diagnosis and therapeutic intervention of this disease. MicroRNA-150 (miR-150) exerts an important influence on the development and function of lymphocytes. However, ...  Read More

Original Article
IL-27 Levels in Bronchoalveolar Lavage Fluid in Children with Post-infectious Bronchiolitis Obliterans

Wenjing Liu; Yiyao Zhang; Xia Chen

Articles in Press, Accepted Manuscript, Available Online from 19 February 2024


  Background: Pulmonary neutrophils may play a crucial role in the development of bronchiolitis obliterans (BO) following measles virus infection. IL-27 could potentially have a negative regulatory effect on the release of reactive oxygen species and cytotoxic granules in neutrophils. Objective: To investigate ...  Read More

Original Article
Serum Interleukin-38 and Tumor-Infiltrating Lymphocytes in Primary Brain Tumors

Mohammad Reza Haghshenas; Aida Khademolhosseini; Amirreza Dehghanian; Fereshteh Ghanipour; Hamid Ghaderi; Soolmaz Khansalar; Abdolreza Sotoodeh Jahromi

Articles in Press, Accepted Manuscript, Available Online from 19 February 2024


  Background: Tumor-infiltrating lymphocytes (TILs) and brain stromal cells produce immunosuppressive cytokines, contributing to an immunosuppressive tumor microenvironment (TME). Interleukin-38 (IL-38) is a novel anti-inflammatory cytokine and a natural modulator of the innate and adaptive immune system. ...  Read More

Original Article
Immunohistochemical Evaluation of NKP46 Receptor Expression and the Number of NK Cells in the Endometrium of Patients with Endometriosis

Mahdi Alimoradi Fard; Mehri Ghafourian; Abdolah Mousavi-Salehi; Farideh Moramazi; Nastaran Ranjbari

Articles in Press, Accepted Manuscript, Available Online from 20 February 2024


  Background: Endometriosis is a medical condition that can cause infertility in women. Women with endometriosis experience a decrease in NK cell cytotoxic activity against endometrial cells, ultimately contributing to the spread of these cells. Objective: To assess the frequency of NK cells and the expression ...  Read More

Shiraz Institute for Cancer Research

Abbas Ghaderi, Distinguished Professor of Immunology

Associate Editor:
Fereshteh Mehdipour, MD, Ph.D.

Managing Editor:
Mahyar Malekzadeh, Ph.D. Candidate

Executive Assistant:
Hamid Ghaderi, DDS

Frequency: Quarterly

Print ISSN: 1735-1383

Online ISSN: 1735-367X

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