Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)

Aim and scope:
The Iranian Journal of Immunology (I.J.I) is an internationally disseminated peer-reviewed publication and publishes a broad range of experimental and theoretical studies concerned with all aspects of immunology.


Types of papers accepted:
The Journal will welcome original and review articles on basic and clinical Immunology, Immunogenetics, Transplantation Immunology, Immunohematology, Cancer Immunology, and Allergy. The Journal will also welcome short papers and letters to the Editor.


Iranian Journal of Immunology is indexed in the following indexing systems: 

  • MEDLINE
  • Web of Science (ISI)
  • SCOPUS
  • EMBASE
  • EMNursing
  • GEOBASE
  • Cambridge Scientific Abstracts
  • Chemical Abstracts
  • Global Health
  • Index Medicus for Eastern Mediterranean Region (IMEMR)

IJI, is an official publication of the Iranian Society for Immunology and Allergy (ISIA), which is published by Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences (SUMS), Shiraz, Iran.

Original Article
Frequency of CD39+, LAG3+, and CTLA4+ Regulatory T Cells in Two Different Immunosuppressive Protocols in Renal Allograft Recipients (Sirolimus vs Mycophenolate mofetil): A Cohort Report

Yaghoub Mollaei-Kandelous; Pedram Ahmadpoor; Mohsen Nafar; Mohammad Reza Khatami; Samad Farashi Bonab; Nader Tajik; Mahdi Shekarabi; Aliakbar Amirzargar

Volume 19, Issue 3 , September 2022, Pages 219-231

http://dx.doi.org/10.22034/iji.2022.92623.2161

Abstract
  Background: Impaired renal function is considered as a significant risk factor for cardiovascular events in chronic kidney disease patients. Several immunosuppressive drugs are used in these patients, which necessitates to minimize the drug-related side effects by employing alternative strategies.Objective: ...  Read More

Original Article
The Proportion of Vδ1T Cells in Peripheral Blood Correlated with Prognosis of Sepsis

Fawei Yuan; Huan Yin; Juan Tan; Kun Zheng; Xiping Mei; Lixue Yuan

Volume 19, Issue 3 , September 2022, Pages 232-242

http://dx.doi.org/10.22034/iji.2022.89256.1934

Abstract
  Background: Sepsis is a serious condition with a high mortality rate, and septic patients often have organ dysfunction, low tissue perfusion and hypoxia, lactic acidosis, oliguria, or functional brain changes.Objective: To observe the number and the function of Vδ1T cells in peripheral blood of ...  Read More

Original Article
Mycobacterium Vaccae Regulate γδT17 and γδTreg Cells in Mice Asthmatic Lung

Yien Yao; Xiaoju Chen; Caicheng Qin; Jianlin Huang; Siyue Xu; Chaoqian Li

Volume 19, Issue 3 , September 2022, Pages 243-254

http://dx.doi.org/10.22034/iji.2022.94460.2311

Abstract
  Background Dysregulation of the balance between different T cell populations is believed to be an important basis for asthma.Objective To observe the changes in γδT subtypes in transgenic asthmatic mice after aerosol inhalation of Mycobacterium vaccae, and to further investigate the mechanism ...  Read More

Original Article
Rosuvastatin Intervention Decreased the Frequencies of the TIM-3+ Population of NK Cells and NKT Cells among Patients with Chronic Hepatitis B

Alireza Norouzi; Shohreh Taziki; Ali Najafipasandi; Saeed Mohammadi; Gholamreza Roshandel

Volume 19, Issue 3 , September 2022, Pages 255-262

http://dx.doi.org/10.22034/iji.2022.93726.2250

Abstract
  Background: Natural killer (NK) cells are dichotomously involved in chronic hepatitis B (CHB) infection as principal members of innate immunity. An effective treatment should enhance the antiviral potentials of NK cells and not their immunomodulatory roles. TIM-3 (T-cell immunoglobulin and mucin-containing ...  Read More

Original Article
Impairment of a NIK-SIX Feedback Axis Results in Dysregulation of Intestinal Immune Homeostasis and Promotes Early-onset Fatal Spontaneous Colitis

Yu Xia Zhao; Hong Mei; Yang Xin Huang; Jia Qing Chen

Volume 19, Issue 3 , September 2022, Pages 263-277

http://dx.doi.org/10.22034/iji.2022.90031.1985

Abstract
  Background: The negative feedback circuit NIK-SIN could inhibit the systemic inflammation and protect mouse from endotoxic shock. However, the physiological significance of NIK-SIX feedback circuit in the maintenance of intestinal immune homeostasis and prevention of early-onset spontaneous colitis is ...  Read More

Original Article
Optimization of an Efficient Cell Culture Hepatitis B Infection System for Assessment of Hepatitis B Virus Neutralizing Monoclonal Antibodies

Hamzeh Sarvnaz; Sahar Asadi-Asadabad; Mohammad Mehdi Amiri; Mojgan Ghaedi; Ulrike Protzer; Mahmood Jeddi-Tehrani; Forough Golsaz-Shirazi; Fazel Shokri

Volume 19, Issue 3 , September 2022, Pages 278-298

http://dx.doi.org/10.22034/iji.2022.94266.2298

Abstract
  Background: Human polyclonal plasma-derived hepatitis B immunoglobulin (HBIG) is currently used for immunoprophylaxis of HBV infection. The development of virus-neutralizing monoclonal antibodies (MAbs) requires the use of optimized cell culture systems supporting HBV infection.Objective: This study ...  Read More

Original Article
Effects of Lipopolysaccharide from Porphyromonas gingivalis and Escherichia coli on Gene Expression Levels of Toll-like Receptors and Inflammatory Cytokines in Human Dental Pulp Stem Cells

Hanieh Mojtahedi; Nikoo Hossein-khannazer; Seyed Mahmoud Hashemi; Mina Masoudnia; Monireh Askarzadeh; Arash Khojasteh; Mandana Sattari

Volume 19, Issue 3 , September 2022, Pages 299-310

http://dx.doi.org/10.22034/iji.2022.92223.2136

Abstract
  Background: Periodontal diseases originate from a group of oral inflammatory infections initiated by oral pathogens. Among these pathogens, Gram-negative bacteria such as p. gingivalis play a major role in chronic periodontitis. P. gingivalis harbours lipopolysaccharide (LPS) which enables it to attach ...  Read More

Original Article
The Chemokine MIG is Associated with an Increased Risk of COVID-19 Mortality in Mexican Patients

Luis Antonio Ochoa-Ramirez; Rosalio Ramos-Payan; German Reynaldo Jimenez-Gastelum; Jose Rodriguez-Millan; Maribel Aguilar-Medina; Juan Jose Rios-Tostado; Alfredo Ayala-Ham; Mercedez Bermudez; Juan Fidel Osuna-Ramos; Vicente Olimon-Andalon; Jesús Salvador Velarde-Félix

Volume 19, Issue 3 , September 2022, Pages 311-320

http://dx.doi.org/10.22034/iji.2022.92641.2162

Abstract
  Background: Coronavirus disease 2019 (COVID-19) is an emergent viral disease in which the host inflammatory response modulates the clinical outcome. Severe outcomes are associated with an exacerbation of inflammation in which chemokines play an important role as the attractants of immune cells to the ...  Read More

Original Article
Comparison of the Antibody Responses Following Vaccination with AstraZeneca and Sinopharm

Enayat Anvari; Atefe Ghamar Talepoor; Mahsa Eshkevar Vakili; Narges Karimi; MohammadReza Ataollahi; Gelareh Najafi; Dieter Kabalitz; Iraj Ahmadi; Kurosh Kalantar

Volume 19, Issue 3 , September 2022, Pages 321-329

http://dx.doi.org/10.22034/iji.2022.94298.2300

Abstract
  Background: Vaccines are the most effective way to prevent Coronavirus 2 severe acute respiratory syndrome (SARS-CoV-2).Objectives: To compare the antibody response of healthy individuals vaccinated with either the AstraZeneca (ChAdOx1 nCoV-19) or the Sinopharm (BBIBP-CorV) vaccine, in those ...  Read More

Review Article
Labor Could Increase Systemic Inflammation and Cause or Deteriorate Cytokine Storm in COVID-19

Amir Hossein Norooznezhad; Alireza A Shamshirsaz; Sedigheh Hantoushzadeh

Volume 19, Issue 3 , September 2022, Pages 330-336

http://dx.doi.org/10.22034/iji.2022.93951.2267

Abstract
  Pregnant women with coronavirus disease 2019 (COVID-19) have a higher risk of morbidity and mortality compared with the general population. Possible pathways are: I) in patients with COVID-19, cytokine storm defined as the excess release of pro-inflammatory cytokines such as interleukin 1β (IL-1β), ...  Read More

Letter To The Editor
Letter to the Editor Regarding "An Overview on Serology and Molecular Tests for COVID-19: An Important Challenge of the Current Century (doi: 10.22034/iji.2021.88660.1894.)"

Milad Zandi; Emad Behboudi; Mohammad Reza Shojaei; Saber Soltani; Hassan Karami

Volume 19, Issue 3 , September 2022, Pages 337-337

http://dx.doi.org/10.22034/iji.2022.91791.2107

Abstract
  Recently in a review article by Mansourabadi et al. published in the Iranian Journal of Immunology, the authors described the serological and molecular tests for COVID-19 (1). The mentioned review considered helicase (Hel) as a structural protein of SARS-CoV-2 (1). However, based on evidence, the genome ...  Read More

The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis

Min Lin; Jin Huang; Wei-Chang Chen; Zhi-Ning Fan; Xihu Qin

Volume 17, Issue 1 , March 2020, , Pages 52-63

http://dx.doi.org/10.22034/iji.2020.80294

Abstract
  Background: Tim-3 has been considered as an ideal target for the immunotherapy of inflammation, but it is unclear whether Tim-3 also plays an important role in acute pancreatitis (AP), as well. Objective: To identify the immunomodulatory effects and mechanisms of Tim-3 action in the early stages of severe ...  Read More

Expression of Human Cytokine Genes Associated with Chronic Hepatitis B Disease Progression
Volume 14, Issue 4 , December 2017, , Pages 281-292

Abstract
  Background: Hepatitis viruses are non-cytopathic viruses that lead to the infection and pathogenesis of liver diseases as a result of immunologically mediated event. Objective: To investigate the expression of human inflammatory cytokines in chronic hepatitis B patients according to the severity of the ...  Read More

Pathogenesis of Atopic Dermatitis: Current Paradigm

Masutaka Furue; Dugarmaa Ulzii; Yen Vu; Gaku Tsuji; Makiko Kido-Nakahara; Takeshi Nakahara

Volume 16, Issue 2 , June 2019, , Pages 97-107

http://dx.doi.org/10.22034/iji.2019.80253

Abstract
  Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles ...  Read More

Airway Inflammatory Biomarker: Could It Tailor the Right Medications for the Right Asthmatic Patient?

Magdy Mohamed Zedan; Amal Mohamed Osman; Wafaa Nabil Laimon; Mohamed Magdy Zedan; Nermin Youssef Abo-elkheir; Ahmed Zaki

Volume 13, Issue 2 , June 2016, , Pages 70-88

Abstract
  Asthma is a heterogeneous disease, in which asthmatic patients present with different clinical phenotypes, variable endotypes, and different response to asthma medicines. Thus, we are faced with an asthma paradox; asthma is diagnosed subjectively by clinical history and treated with biologically active ...  Read More

Publisher:
Shiraz Institute for Cancer Research

Editor-in-Chief:
Abbas Ghaderi, Distinguished Professor of Immunology

Associate Editor:
Fereshteh Mehdipour, MD, Ph.D.

Editorial Manager:
Mahyar Malekzadeh, Ph.D. Student

Executive Assistant:
Hamid Ghaderi, DDS


Frequency: Quarterly

Print ISSN: 1735-1383

Online ISSN: 1735-367X

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