Volume 20 (2023)
Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)

Aim and scope:
The Iranian Journal of Immunology (I.J.I) is an internationally disseminated peer-reviewed publication and publishes a broad range of experimental and theoretical studies concerned with all aspects of immunology.

Types of papers accepted:
The Journal will welcome original and review articles on basic and clinical Immunology, Immunogenetics, Transplantation Immunology, Immunohematology, Cancer Immunology, and Allergy. The Journal will also welcome short papers and letters to the Editor.

Iranian Journal of Immunology is indexed in the following indexing systems: 

  • Web of Science (ISI)
  • EMNursing
  • Cambridge Scientific Abstracts
  • Chemical Abstracts
  • Global Health
  • Index Medicus for Eastern Mediterranean Region (IMEMR)

IJI, is an official publication of the Iranian Society for Immunology and Allergy (ISIA), which is published by Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences (SUMS), Shiraz, Iran.

Review Article
Functional Property and Regulatory Mechanism of Macrophages in Complementary and Alternative Medicine: From Bench to Clinic

Can Hu; Yizhi Zhang; Junjiang Liu; Yanyan You; Fanglong Wu; Hongmei Zhou

Volume 21, Issue 2 , June 2024, Pages 103-120


  Complementary and alternative medicine (CAM) includes a wide range of treatments that are gaining acceptance among the public. It is increasingly being recognized as a viable option for treating various diseases with minimal side effects. Common avenues of this therapy include herbal medicine, acupuncture, ...  Read More

Original Article
Natural Killer Cell Subsets in Tumor Draining Lymph Nodes of Patients with Bladder Cancer and Their Clinical Implications

Ali Ariafar; Erfan Kohansal; Amirhassan Mousania; Zahra Faghih

Volume 21, Issue 2 , June 2024, Pages 121-131


  Background: Natural killer (NK) cells are crucial innate components in anti-tumor immunity. However, the clinical impacts and their phenotypes in bladder cancer (BC) remain unclear.Objective: To assess the clinical significance of NK cell subsets in tumor-draining lymph nodes of patients with BC.Methods: ...  Read More

Original Article
Glycyrrhiza Glabra Extract Modulates Type 1 T Helper (TH1) and Regulatory T Cell-Related Immune Responses in an Animal Model of Breast Cancer

Soheila Yousefi; Pedram Basirjafar; Raziyeh Zandvakili; Javad Masoumi; Nahid Zainodini; Hossein Khorramdelazad; Mahsa Gheitasi; Abdollah Jafarzadeh

Volume 21, Issue 2 , June 2024, Pages 132-146


  Background: It is well-known that TH1 and Treg cells exert anti- and pro-tumorigenic activity, respectively. Thus, TH1 cell suppression together with Treg cell hyperactivation contribute to tumor development. Glycyrrhiza glabra (G. glabra) has various immunomodulatory and anti-tumorigenic properties.Objective: ...  Read More

Original Article
Evaluation of Monocyte Subpopulations in Patients with Systemic Sclerosis and its Association with Clinical Manifestations of the Disease: a Cross-sectional Controlled Study

Elham Safarzadeh; Vahid Asghariazar; Shohreh Pordel; Elham Baghbani; Asgar Fekri; Afsaneh Enteshari-Moghaddam

Volume 21, Issue 2 , June 2024, Pages 147-157


  Background: Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized not only by fibrosis and vasculopathy but also by inflammation. Previous studies have demonstrated monocyte involvement in SSc development, suggesting a role for immune dysfunction in SSc pathogenesis.Objective: To investigate ...  Read More

Original Article
The Effect of Interferon Beta and Natalizumab on miR-20b Expression in Patients with Relapsing-Remitting Multiple Sclerosis is Potentially Mediated by Modulation of the Jak–STAT Signaling Pathway: A Case-control Study

Aysan Jafari Harandi; Alireza Mirzaee Sedigh; Mitra Ataei; Sepideh Bayrami; Emran Esmaeilzadeh; Mohammad Hossein Sanati

Volume 21, Issue 2 , June 2024, Pages 158-165


  Background: The mechanisms of the function of interferon beta (IFN-β) and natalizumab (NTZ) in multiple sclerosis (MS) patients have not yet been fully understood. Over the past decades, many studies have been conducted to evaluate gene expression changes especially regulatory non-coding RNAs such ...  Read More

Original Article
Evaluation of PD-1 Gene Expression Profile and Methylation of the Regulatory Regions in Patients with Ankylosing Spondylitis

Narjes Soleimanifar; Sara Assaadiasl; Mohammed Sameer Al-Shammari; Abdol-Rahman Rostamian; Maryam Sadr; Sepideh Shahkarami; Hanieh Mojtahedi; Mohammad Hossein Nicknam

Volume 21, Issue 2 , June 2024, Pages 166-175


  Background: Ankylosing spondylitis (AS) is a chronic autoimmune disorder characterized by the fusion of vertebral joints and axial arthritis. The programmed death-1 (PD-1) inhibitory receptor has a pivotal role in controlling T cell function and may have a significant impact on the pathogenesis of ...  Read More

Case Report
Outcome of Cyclophosphamide Treatment Following Hematopoietic Stem Cell Transplantation in a Thalassemia Patient: A Case Study

Heba M. Bahlol; Sohaila M. Khalil; Mohamed R. El-Shanshory; Mohamed L. Salem

Volume 21, Issue 2 , June 2024, Pages 176-183


  Hematopoietic stem cell transplantation (HSCT) is the only curative therapy for β-thalassemia major in children. However, it often induces graft-versus-host-disease (GVHD), which is associated with complications. In the present study, we used cyclophosphamide (Cy) to treat a thalassemia patient ...  Read More

Letter To The Editor
Letter to the Editor Regarding “Comparative Immunogenicity and Neutralization Potency of Four Approved COVID-19 Vaccines in BALB/c Mice”

Hineptch Daungsupawong; Viroj Wiwanitkit

Volume 21, Issue 2 , June 2024, Pages 184-185


  Dear EditorWe are writing to discuss the article titled “Comparative Immunogenicity and Neutralization Potency of Four Approved COVID-19 Vaccines in BALB/c Mice” (1). The study examined the immunogenicity and neutralization efficacy of four COVID-19 vaccines licensed in Iran in BALB/c mice. ...  Read More

The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis

Min Lin; Jin Huang; Wei-Chang Chen; Zhi-Ning Fan; Xihu Qin

Volume 17, Issue 1 , March 2020, , Pages 52-63


  Background: Tim-3 has been considered as an ideal target for the immunotherapy of inflammation, but it is unclear whether Tim-3 also plays an important role in acute pancreatitis (AP), as well. Objective: To identify the immunomodulatory effects and mechanisms of Tim-3 action in the early stages of severe ...  Read More

Pathogenesis of Atopic Dermatitis: Current Paradigm

Masutaka Furue; Dugarmaa Ulzii; Yen Vu; Gaku Tsuji; Makiko Kido-Nakahara; Takeshi Nakahara

Volume 16, Issue 2 , June 2019, , Pages 97-107


  Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles ...  Read More

Expression of Human Cytokine Genes Associated with Chronic Hepatitis B Disease Progression
Volume 14, Issue 4 , December 2017, , Pages 281-292

  Background: Hepatitis viruses are non-cytopathic viruses that lead to the infection and pathogenesis of liver diseases as a result of immunologically mediated event. Objective: To investigate the expression of human inflammatory cytokines in chronic hepatitis B patients according to the severity of the ...  Read More

Role of Interleukin-37 in Inflammatory and Autoimmune Diseases

Xiaoying Wang; Keye Xu; Sisi Chen; Yan Li; Mingcai Li

Volume 15, Issue 3 , September 2018, , Pages 165-174


  Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 suppression. IL-37 also translocates to the cell ...  Read More

Original Article
The Protective Role of IL-17 and IL-22 in COVID-19 Infection

Sengul Aksakal; Selim Gorgun

Articles in Press, Accepted Manuscript, Available Online from 01 June 2024


  Background: The development of a cytokine storm in Coronavirus Disease 2019 (COVID-19) infection can make the disease fatal. We hypothesize that this excessive cytokine production impairs mucosal healing. IL-17 and IL-22 are cytokines that play a key role in protecting and regenerating mucosal tissues.IL-17 ...  Read More

Shiraz Institute for Cancer Research

Abbas Ghaderi, Distinguished Professor of Immunology

Associate Editor:
Fereshteh Mehdipour, MD, Ph.D.

Managing Editor:
Mahyar Malekzadeh, Ph.D. Candidate

Executive Assistant:
Hamid Ghaderi, DDS

Frequency: Quarterly

Print ISSN: 1735-1383

Online ISSN: 1735-367X

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