Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)

Aim and scope:
The Iranian Journal of Immunology (I.J.I) is an internationally disseminated peer-reviewed publication and publishes a broad range of experimental and theoretical studies concerned with all aspects of immunology.

Types of papers accepted:
The Journal will welcome original and review articles on basic and clinical Immunology, Immunogenetics, Transplantation Immunology, Immunohematology, Cancer Immunology, and Allergy. The Journal will also welcome short papers and letters to the Editor.

Iranian Journal of Immunology is indexed in the following indexing systems: 

  • Web of Science (ISI)
  • EMNursing
  • Cambridge Scientific Abstracts
  • Chemical Abstracts
  • Global Health
  • Index Medicus for Eastern Mediterranean Region (IMEMR)

IJI, is an official publication of the Iranian Society for Immunology and Allergy (ISIA), which is published by Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences (SUMS), Shiraz, Iran.

Original Article
1. TLR9/NF-kB Pathway Regulates Brucella CpG DNA-mediated Cytokine Response in Human Peripheral Blood Mononuclear Cells

Yunzhi Peng; Wenhui Bai; Zhanli Wang; Hui Yu

Volume 18, Issue 4 , Autumn 2021, Pages 268-278


  Background: It was reported that targeting the Toll-like receptor9(TLR9) signaling pathway can be a promising therapeuticstrategy forinterventions in various inflammatory and infectiousdiseases. However,it was not known whether the human TLR9 isresponsive to Brucellacytidine-phosphate-guanosine (CpG) ...  Read More

Original Article
2. Advax, as a Co-adjuvant, in Combination with Poly(I:C) Elicits Enhanced Th1 Immune Responses and Parasite Growth-Inhibitory Antibodies Against Plasmodium falciparum Merozoite Surface Protein-1 (PfMSP-142) in BALB/c Mice

Akram Abouie Mehrizi; Saeed Bagheri Verjani; Sedigheh Zakeri

Volume 18, Issue 4 , Autumn 2021, Pages 279-291


  Background: One of the main challenges in protein-based vaccines is the poor immunogenicity of antigens, which can be solved by the use of adjuvants. Advax is a novel microparticle polysaccharide adjuvant that in combination with antigens can induce both cellular and humoral immunity based on the intrinsic ...  Read More

Original Article
3. Immunological Properties of Exotoxin A Toxoid - Detoxified Lipopolysaccharide - Gold Nanoparticles Conjugate Against Pseudomonas aeruginosa Infection

Faezeh Najafzadeh; Asghar Tanomand; Azam Hadadi; Jafar Majidi

Volume 18, Issue 4 , Autumn 2021, Pages 292-303


  Background: Pseudomonas aeruginosa is an important opportunistic pathogen, especially in patients with compromised host defense. Objective: To prepare the conjugate of detoxified lipopolysaccharide (D-LPS) and exotoxin A toxoid (T-ETA) from P. aeruginosa in gold nanoparticles (Au NPs) in a mice model. ...  Read More

Original Article
5. Upregulation of Interleukin-6 in HPV-Positive Breast Cancer Patients

Javad Charostad; Azarakhsh Azaran; Mohsen Nakhaei; Akram Astani; Gholam Abbas Kaydani; Azim Motamedfar; manoochehr makvandi

Volume 18, Issue 4 , Autumn 2021, Pages 315-330


  Background: Interleukin-6 (IL-6) is a well-known proinflammatory cytokine with tumor promoting capacity in various forms of malignancies including breast cancer (BC). Data highlighted the substantial role of HPV in the pathogenesis of BC. Compelling evidence suggests the contribution of HPV in carcinogenesis ...  Read More

Short Communication
6. More Evidence of the Link of Interleukin-6 and Interleukin-10 with Critical COVID-19: A Report in Mexican Patients

German Reynaldo Jiménez-Gastélum; Arely Monserrant Espinoza-Ortega; Rosalío Ramos-Payán; Maribel Aguilar-Medina; Jorge López-Gutiérrez; Carlos Villegas-Mercado; Luis Antonio Ochoa-Ramirez; Horacio Rendón-Aguilar; Juan Fidel Osuna-Ramos; Juan José Ríos-Tostado; Jesús Salvador Velarde-Félix

Volume 18, Issue 4 , Autumn 2021, Pages 331-337


  Background: According to the World Health Organization, Mexico presents one of the highest mortality rates due to coronavirus disease 2019 (COVID-19). The "cytokine storm" phenomenon has been proposed as a pathological hallmark of severe COVID-19. Objective: To determine the association of serum cytokine ...  Read More

Original Article
7. Evaluation of the Relationship between Pro-Inflammatory Cytokine Levels and Clinical Findings of Fibromyalgia Syndrome

Pınar Ellergezen; Alev ALP; Sinan Çavun

Volume 18, Issue 4 , Autumn 2021, Pages 338-345


  Background: Immune system has an important effect on pain-related disorders such as fibromyalgia syndrome (FMS). There is no specific laboratory technique for the diagnosis of FMS, but measuring serum proinflammatory cytokines may help. Objective: The purpose of our study was to determine the serum levels ...  Read More

Original Article
8. Elevated IL-37 Serum Levels in Patients with Transitional Cell Carcinoma of Bladder

Mohammad Reza Haghshenas; Seyed Reza Hosseini; Mohammad Javad Fattahi; Mahyar Malekzadeh; Ali Aryafar; Abbas Ghaderi

Volume 18, Issue 4 , Autumn 2021, Pages 346-353


  Background: Interleukin-37 (IL-37) is a recently described cytokine that emerges as a natural inhibitor of inflammatory and immune responses. However, IL-37 has not yet been investigated in bladder cancer, and its biological role is unknown. Objective: The purpose of this study was to investigate IL-37 ...  Read More

Original Article
9. Comprehensive Analysis of the HLA Class I and the HLA class II Alleles in Patients with Takayasu Arteritis: Relationship with Clinical Patterns and Prognosis

Maja Stojanovic; Zorana Andric; Dusan Popadic; Marija Stankovic Stanojevic; Rada Miskovic; Dragana Jovanovic; Aleksandra Peric Popadic; Jasna Bolpacic; Vesna Tomic-Spiric; Sanvila Raskovic

Volume 18, Issue 4 , Autumn 2021, Pages 354-365


  Background: Takayasu arteritis (TA) is a systemic vasculitis, affecting mainly the aorta and its branches. Objective: To analyze the HLA class I and class II alleles in patients with TA and explore their relationship with clinical and demographic characteristics, and potential significance in prognosis. ...  Read More

1. The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis

Min Lin; Jin Huang; Wei-Chang Chen; Zhi-Ning Fan; Xihu Qin

Volume 17, Issue 1 , Winter 2020, , Pages 52-63


  Background: Tim-3 has been considered as an ideal target for the immunotherapy of inflammation, but it is unclear whether Tim-3 also plays an important role in acute pancreatitis (AP), as well. Objective: To identify the immunomodulatory effects and mechanisms of Tim-3 action in the early stages of severe ...  Read More

2. Expression of Human Cytokine Genes Associated with Chronic Hepatitis B Disease Progression
Volume 14, Issue 4 , Autumn 2017, , Pages 281-292

  Background: Hepatitis viruses are non-cytopathic viruses that lead to the infection and pathogenesis of liver diseases as a result of immunologically mediated event. Objective: To investigate the expression of human inflammatory cytokines in chronic hepatitis B patients according to the severity of the ...  Read More

3. Pathogenesis of Atopic Dermatitis: Current Paradigm

Masutaka Furue; Dugarmaa Ulzii; Yen Vu; Gaku Tsuji; Makiko Kido-Nakahara; Takeshi Nakahara

Volume 16, Issue 2 , Spring 2019, , Pages 97-107


  Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles ...  Read More

4. Airway Inflammatory Biomarker: Could It Tailor the Right Medications for the Right Asthmatic Patient?

Magdy Mohamed Zedan; Amal Mohamed Osman; Wafaa Nabil Laimon; Mohamed Magdy Zedan; Nermin Youssef Abo-elkheir; Ahmed Zaki

Volume 13, Issue 2 , Spring 2016, , Pages 70-88

  Asthma is a heterogeneous disease, in which asthmatic patients present with different clinical phenotypes, variable endotypes, and different response to asthma medicines. Thus, we are faced with an asthma paradox; asthma is diagnosed subjectively by clinical history and treated with biologically active ...  Read More

5. Efficiency and Impact of Positive and Negative Magnetic Separation on Monocyte Derived Dendritic Cell Generation

Marek Fol; Magdalena Kowalewicz-Kulbat; El ż bieta Ograczyk; Marcin W ł odarczyk; Krzysztof Krawczyk

Volume 13, Issue 2 , Spring 2016, , Pages 132-140

  Background: The immunomagnetic separation technique is the basis of monocyte isolation and further generation of monocyte-derived dendritic cells. Objective: To compare the efficiency of monocyte positive and negative separation, concentration of beads, and their impact on generated dendritic cells. ...  Read More

Shiraz Institute for Cancer Research

  Abbas Ghaderi, Distinguished Professor of Immunology

Associate Editor:
  Fereshteh Mehdipour, MD, Ph.D.

Editorial Manager:
  Mahyar Malekzadeh, Ph.D. Student

Executive Assistant:
  Hamid Ghaderi

Print ISSN: 1735-1383

Online ISSN: 1735-367X

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