Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
1. GPI-Anchored Fibromodulin as a Novel Target in Chronic Lymphocytic Leukemia: Diagnostic and Therapeutic Implications

Lia Farahi; Fatemeh Ghaemimanesh; Saeideh Milani; Seyed Mohsen Razavi; Reza Hadavi; Ali Ahmad Bayat; Ali Salimi; Mohammad Mehdi Akhondi; Hodjattallah Rabbani

Volume 16, Issue 2 , Spring 2019, , Pages 127-141


  Background: We have previously reported the aberrant expression of Fibromodulin (FMOD) in patients with chronic lymphocytic leukemia (CLL). Although FMOD has been considered as a cytoplasmic or secretory protein, we discovered the cell surface expression of FMOD in leukemic B cells via anchoring with ...  Read More

2. A Novel mAb against a Human CD34 Peptide Reacts with the Native Protein on CD34+ Cells

Mahmood Shams; Mahmood Jeddi-Tehrani; Farzaneh Notash Haghighat; Ali Ahmad Bayat; Jafar Mahmoudian; Mohammad Reza Rezvani

Volume 10, Issue 4 , Autumn 2013, , Pages 259-266

  Background: Human CD34 is a transmembrane glycoprotein which is expressed in human hematopoietic stem cells (HSCs) and the small- vessel endothelial cells of a variety of tissues. CD34 plays a critical role as a marker for diagnosis and classification of leukemia. Anti CD34 antibodies are used for isolation ...  Read More

3. Construction and Expression of Hepatitis B Surface Antigen Escape Variants within the "a" Determinant by Site Directed Mutagenesis

Forough Golsaz Shirazi; Mohammad Mehdi Amiri; Hamed Mohammadi; Ali Ahmad Bayat; Azam Roohi; Jalal Khoshnoodi; Amir Hassan Zarnani; Mahmood Jeddi-Tehrani; Gholam Ali Kardar; Fazel Shokri

Volume 10, Issue 3 , Summer 2013, , Pages 127-138

  Background: The antibody response to hepatitis B surface antigen (HBsAg) controls hepatitis B virus infection. The "a" determinant of HBsAg is the most important target for protective antibody response, diagnosis and immunoprophylaxis. Mutations in this area may induce immune escape mutants and affect ...  Read More

4. Heterologous Immunization, a Way out of the Problem of Monoclonal Antibody Production against Carcinoma Antigen 125

Sorour Shojaeian; Amir Hassan Zamani; Mahmood Jeddi-Tehrani; Forouzandeh Fereidooni; Ebrahim Torkabadi; Mohammad Mehdi Akhondi; Akram Sadat Tabatabaei-Panah; Abdolamir Allameh

Volume 6, Issue 4 , Autumn 2009, , Pages 174-185

  Background: Monoclonal antibodies (mAbs) are essential tools for many molecular im-munology investigations, epitope mapping and molecular modelling, clinical laboratory di-agnostic tests and immunotherapy. Humoral immune response of immunized animals largely depends on the nature of antigen and the immunization ...  Read More

5. Production and Characterization of Monoclonal Antibody against Saffron Pollen Profilin, Cro s 2

Mojtaba Sankian; Forough Glosaze Shirazi; Mahid Arafi; Malihe Moghadam; Abdolreza Varasteh

Volume 5, Issue 3 , Summer 2008, , Pages 156-162

  Background: Allergy to Saffron (Crocus sativus) pollen has been described in people involved in processing of saffron flower stamens. Profilins have been identified as a pan-allergen in different plant pollens and foods. This molecule is an actin-binding pro-tein with a molecular weight of 12-16 kDa ...  Read More

6. Production and Characterization of Murine Monoclonal Antibodies Recognizing Conformational and Linear Epitopes Localized on Human IgA2 Molecules

Fatemeh Hajighasemi; Soheila Gharagozlou; Nasrin Moheghi; Roya Ghods; Jalal Khoshnoodi; Fazel Shokri

Volume 2, Issue 3 , Summer 2005, , Pages 125-133

  Background: There are two subclasses of human IgA (IgA1 and IgA2) that differ in antigenic properties and in chemical composition. The constant domains of α1 and α2 heavy chains have >95% sequence homology though major structural differences exist in the hinge region. Quantitation of IgA ...  Read More

7. Measurement of Affinity Constant of Anti-human IgG Monoclonal Antibodies by an ELISA-based Method

Fatemeh Hajighasemi; Ali Akbar Saboor-Yaraghi; Fazel Shokri

Volume 1, Issue 3 , Autumn 2004, , Pages 154-161

  Background: The affinity of an antibody to its antigen is a crucial parameter in its biological activity and performance of an immunoassay such as ELISA. Affinity of most IgG specific MAbs are often determined by methods which require labeling of either antigen or antibody, and are sometimes difficult ...  Read More

8. Production and Characterization of Murine Monoclonal Antibodies to Leishmania Gp63 Antigen

Ezzatallah Basiri; Sadreddin Mohseni Ardehali; Mehrnoosh Doroudchi; Fereidoun Mahboodi; Arsalan Kharazmi; Abbas Ghaderi

Volume 1, Issue 3 , Autumn 2004, , Pages 194-199

  Background : Production of monoclonal antibodies to Leishmania antigens assists the identification and characterization of these organisms. Objective: Production of monoclonal antibodies against epitopes on the gp63. Methods: Two murine monoclonal antibodies to gp63 were produced and characterized. The ...  Read More