Background: Allergic diseases have increased during the past decade worldwide. Th2 type lymphocyte response is known to play an important role in the process of allergic inflammation. IL-4, a mediator of type II cytokine response increases IgE synthesis and Interferon gamma, a cytokine of type I response interferes with IL-4 and inhibits IgE production. Selenium is an essential component of glutathione peroxides and changes in its plasma level has been proposed to be associated with allergic diseases. Materials and Methods: This study comprised of 21 cases of allergic asthma (AA), 33 cases of allergic rhinitis (AR) whose age and sex were matched with 28 healthy controls. IL-4, IL-10, IFN-g levels were tested by ELISA assay, and serum selenium was measured by atomic absorption spectorphotometery method. Results: Mean serum selenium level of AA and AR groups were lower than controls. Mean serum IL-4 level of AA was higher than the AR group. Mean serum IL-4 level of AA and AR group were higher than controls. Conclusion: The results of this study indicate that low selenium level may have a role in the pathogenesis of allergic diseases.
Farid, R., Jabbari Azad, F., Gaffari, J., Rangbar, A. & Nikjoy, Z. (2004). Serum Level of Selenium, IL-4, IL-10 & IFN-g in Patients with Allergic Asthma, Allergic Rhinitis and Healthy Controls. Iranian Journal of Immunology, 1(1), 71–75. https://doi.org/10.22034/iji.2004.16710
MLA
Farid, R., Jabbari Azad, F., Gaffari, J., Rangbar, A., & Nikjoy, Z. "Serum Level of Selenium, IL-4, IL-10 & IFN-g in Patients with Allergic Asthma, Allergic Rhinitis and Healthy Controls", Iranian Journal of Immunology, 1, 1, 2004, 71–75. doi: 10.22034/iji.2004.16710
HARVARD
Farid, R., Jabbari Azad, F., Gaffari, J., Rangbar, A., & Nikjoy, Z. (2004). 'Serum Level of Selenium, IL-4, IL-10 & IFN-g in Patients with Allergic Asthma, Allergic Rhinitis and Healthy Controls', Iranian Journal of Immunology, 1(1), pp. 71–75. doi: 10.22034/iji.2004.16710
CHICAGO
Farid, R., Jabbari Azad, F., Gaffari, J., Rangbar, A. & Nikjoy, Z., "Serum Level of Selenium, IL-4, IL-10 & IFN-g in Patients with Allergic Asthma, Allergic Rhinitis and Healthy Controls." Iranian Journal of Immunology, 1 1 (2004): 71–75, doi: 10.22034/iji.2004.16710
VANCOUVER
Farid R., Jabbari Azad F., Gaffari J., Rangbar A., Nikjoy Z. Serum Level of Selenium, IL-4, IL-10 & IFN-g in Patients with Allergic Asthma, Allergic Rhinitis and Healthy Controls. Iran.J.Immunol. 2004;1(1):71–75. doi: 10.22034/iji.2004.16710
