Iranian Journal of Immunology

Serum Levels of Monocyte Chemoattractant Protein-1 Correlate with Poor Clinical Grades in Cerebral Aneurysms

Document Type : Original Article

Authors

Abdolkarim Rahmanian 1
Navideh Mohebali 1
Ali Haghnegahdar 1
Eskandar Kamali Sarvestani 2
Ali Razmkon 1
Juri Kivelev 3
Fahim Baghban 1

1 Department of Neurosurgery

2 Department of Immunology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran

3 Department of Neurosurgery, Helsinki University Central Hospital, Topeliuksenkatu, Finland

https://doi.org/10.22034/iji.2015.16758
Abstract
Background : Ruptured cerebral aneurysms (ICAs) are the most common non-traumatic cause of subarachnoid hemorrhage (SAH) that is associated with life threatening complications such as Vasospasm, Infarction, and Hydrocephalus (HCP). The active participation of macrophage/monocyte-mediated inflammatory response in the pathogenesis of cerebral aneurysm as labeled with Monocyte ChemoattractantProtein-1 (MCP-1) is suggested.
Objective: To measure the serum level of MCP-1 in ruptured CAs in different time intervals .
Methods: We measured the serum levels of MCP-1 in SAH patients who had CAs and compared it with that of MCP-1 in two control groups: including patients with SAH without CAs, and the normal population of blood donors. We also measured the MCP-1 levels in patients with CAs one week afterward to evaluate the effect of treatment. Serum level of MCP-1 was measured by a commercial ELISA assay.
Results: Mean serum MCP-1 level in patients with SAH and CAs was 188.2168 Pg/ml and 331.3982 Pg/ml in the normal population. There was no statistically significant difference between serum levels of MCP-1 on the first (mean=188.2168 Pg/ml) and 7 th days after SAH onset (mean=171.8450 Pg/ml) (p=0.739). Serum level of MCP-1 increased significantly as Glasgow Coma Scale decreased (p=0.078) and Hunt and Hess score increased (p=0.089).
Conclusion: Our results did not show an increasing MCP-1 serum level in patients with aneurysmal SAH. There was a relationship between poor clinical grade and MCP-1 levels in patients with CAs. MCP-1 may be a local inflammatory marker for cerebral aneurysms without systemic manifestation.

Keywords

Intracranial Aneurysm
Level
Monocyte Chemoatractic Protein 1
serum
Iranian Journal of Immunology
Volume 12, Issue 4
Autumn 2015
Pages 302-310

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