Iranian Journal of Immunology

Differential Immunogenicity of A Recombinant Hepatitis B Vaccine in Iranian Neonates: Influence of Ethnicity and Environmental Factors

Document Type : Original Article

Authors

Abdollah Jafarzadeh 1, 2
Jalal Khoshnoodi 1
Shayesteh Ghorbani 3
Saleh Mohaghegh Hazrati 1, 4
Babak Faraj Mazaheri 4
Fazel Shokri 1

1 Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran

2 Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan

3 Kerman Health Center, Kerman University of Medical Sciences, Kerman

4 Health Research Center of Urmia, Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran

https://doi.org/10.22034/iji.2004.16791
Abstract

Objective: To compare immunogenicity of a recombinant hepatitis B (HB) vaccine in two groups of neonates born in two cities of Iran with different geographic and ethnic backgrounds.   Materials and
Methods: Ten micrograms of a recombinant HB vaccine was administered under field condition to Iranian healthy neonates at 0, 1.5 and 9 months intervals. The subjects consisted of two groups of 290 and 231 neonates selected from two cities located at north-west (Urmia) and south-east (Kerman) of Iran, respectively. The level of anti-HBs antibody was quantitated in serum 2-4 weeks after administration of the last vaccine dose, by sandwich ELISA.  
Results: A higher seroprotection rate (anti-HBs> 10 IU/L) (98.3% vs. 96.1%) and significantly increased serum anti- HBs antibody titer (11869 vs. 6104 IU/L) (P<0.001) were induced in vaccinated neonates from Urmia city, compared to those born in Kerman.  
Conclusion: These findings suggest contribution of ethnic and/or environmental factors in the antibody response to recombinant HB vaccine in human.

Keywords

Ant i-HBs antibody
Hepatitis B
Vaccinat ion
Immunogenicit y
neonate
Seroprotection
Iranian Journal of Immunology
Volume 1, Issue 2 - Serial Number 2
Summer 2004
Pages 98-104

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