Iranian Journal of Immunology

Association of IFN-¹ Gene Polymorphism with Type 1 Diabetes in Iranian Patients

Document Type : Original Article

Authors

Ali Rafinejad 1
Mohammad Hossein Niknam 1
Ali Akbar Amirzargar 1
Farideh Khosravi 1
Forouzan Karimi 2
Bagher Larijani 3

1 Department of Immunology, School of Medicine, Tehran University of Medical Sciences

2 Iranian National Research Center for Medical Sciences of I.R. IRAN

3 Endocrinology and Metabolism Research Center, Tehran, Iran.

https://doi.org/10.22034/iji.2004.16796
Abstract
Background: Type 1 Diabetes (T1D) is a chronic and progressive autoimmune disorder. Cytokines play a critical role in the pathogenesis of T1D.  
Objective: IFN-¹ polymorphism was investigated in T1D and compared with normal controls.  
Methods: Thirty patients suffering from T1D and 40 normal controls were studied simultaneously using PCR technique. IFN-   ¹ gene was evaluated at position 5’UTR +5644.
Results: There was a significant difference between patient and control groups in TT genotype (P<0.05).
Conclusion: In this study, we found a negative association between IFN-¹ gene at position 5’UTR +5644 and T1D in Iranian patients pointing to T allele as a protective factor against T1D.

Keywords

Cytokine
Polymorphism
Type 1 Diabetes Mellitus
Iranian Journal of Immunology
Volume 1, Issue 2 - Serial Number 2
Summer 2004
Pages 130-132

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