Document Type : Original Article
Authors
- Ali Rafinejad 1
- Mohammad Hossein Niknam 1
- Ali Akbar Amirzargar 1
- Farideh Khosravi 1
- Forouzan Karimi 2
- Bagher Larijani 3
1 Department of Immunology, School of Medicine, Tehran University of Medical Sciences
2 Iranian National Research Center for Medical Sciences of I.R. IRAN
3 Endocrinology and Metabolism Research Center, Tehran, Iran.
Abstract
Background: Type 1 Diabetes (T1D) is a chronic and progressive autoimmune disorder. Cytokines play a critical role in the pathogenesis of T1D.
Objective: IFN-¹ polymorphism was investigated in T1D and compared with normal controls.
Methods: Thirty patients suffering from T1D and 40 normal controls were studied simultaneously using PCR technique. IFN- ¹ gene was evaluated at position 5’UTR +5644.
Results: There was a significant difference between patient and control groups in TT genotype (P<0.05).
Conclusion: In this study, we found a negative association between IFN-¹ gene at position 5’UTR +5644 and T1D in Iranian patients pointing to T allele as a protective factor against T1D.
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