Document Type : Original Article


1 Department of Immunology, School of Medicine, Tehran University of Medical Sciences

2 Iranian National Research Center for Medical Sciences of I.R. IRAN

3 Endocrinology and Metabolism Research Center, Tehran, Iran.


Background: Type 1 Diabetes (T1D) is a chronic and progressive autoimmune disorder. Cytokines play a critical role in the pathogenesis of T1D.  
IFN-¹ polymorphism was investigated in T1D and compared with normal controls.  
Thirty patients suffering from T1D and 40 normal controls were studied simultaneously using PCR technique. IFN-   ¹ gene was evaluated at position 5’UTR +5644.
There was a significant difference between patient and control groups in TT genotype (P<0.05).
Conclusion: In this study, we found a negative association between IFN-¹ gene at position 5’UTR +5644 and T1D in Iranian patients pointing to T allele as a protective factor against T1D.