Iranian Journal of Immunology

Placental Transfer of Respiratory Syncytial Virus-Specific IgG in Iranian Mothers

Document Type : Original Article

Authors

Mehrnoosh Doroudchi 1, 2
Hamidreza Dehshiri 3
Alamtaj Samsami Dehaghani 4

1 Department of Immunology

2 Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz

3 Department of Biology, Islamic Azad University, Jahrom

4 Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran

10.22034/iji.2004.16813
Abstract
Background: Respiratory Syncytical virus infection is the most common cause of bronchiolitis and viral pneumonia in infancy.
Objective: To investigate the placental transfer of RSV-specific IgG in Iranian mothers.
Methods: The antibodies were measured in sera of 146 mother/newborn pairs using a commercially available indirect Enzyme Linked Immunosorbent Assay (ELISA). The studied subjects were among healthy pregnant women who attended to the Zeinabieh Hospital of Shiraz University of Medical Sciences in a one year period.
Results: A highly significant correlation was observed between RSV-specific IgG in newborns and mothers (r = 0.88). However, mean RSV-specific IgG antibodies in neonates was significantly higher than that of their mothers (P = 0.019). In addition, the mean cord/maternal ratio of RSV-specific IgG was detected to be 1.27 ± 0.60. Maternal blood group, age, parity, previous abortions and neonatal gestational age had no correlation with placental transfer of RSV-specific IgG antibodies.
Conclusion: Our finding demonstrates that placental transfer of RSV-specific IgG antibodies is an active process and the main factor that influences this transfer is maternal concentration of these immunoglobulins.

Keywords

IgG
Iranian
Placental Transfer
RSV
Iranian Journal of Immunology
Volume 1, Issue 3 - Serial Number 3
Autumn 2004
Pages 183-188

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