Iranian Journal of Immunology

Antioxidants and Proinflamatory Cytokines in the Sera of Patients with Cutaneous Leishmaniasis

Document Type : Short Paper

Authors

Afshineh Latifynia 1
Ali Khamesipour 2
Saied Bokaie 3
Nematollah Khansari 1

1 Department of Immunology, Faculty of Medicine

2 Leprosy and Dermal Disease Center, Tehran University of Medical Sciences

3 Department of Pathobiology, Veterinary Medicine, Tehran University of Medical Sciences, Tehran, Iran

https://doi.org/10.22034/iji.2012.16873
Abstract
Background: Leishmania is a significant health problem in many parts of the world. Tumor necrosis factor (TNF) plays an essential role in Leishmania major infections.
Objective: To study the pro-inflammatory cytokines and antioxidants in four groups of cutaneous leishmaniasis patients.
Methods: 39 patients were divided into four groups of: 1) active (acute phase of treatment); 2) non-healing (received treatment for almost two years without recovery); 3) healing (recovered upon treatment); and 4) healed (previously received treatment and achieved complete remission) patients. Serum levels of pro-inflammatory cytokines (IL-1B, TNF-α, IL-6) and serum antioxidant levels were measured by ELISA and FRAP assays, respectively.
Results: While serum antioxidant levels were elevated in the non-healing group, there was no difference among other groups of patients and healthy controls in this regard. Interleukin-1β showed the highest level in the non-healing group followed by the other groups of patients. The mean serum IL-6 level was highest in the non-healing group, but showed no significant change in the other groups. TNF-α and IL-1β levels were non-significantly elevated in the sera of active and non-healing patients.
Conclusion: Pro-inflammatory cytokines IL-1β, TNF-α, IL-6 maybe related to the progression of leishmaniasis. Serum antioxidant levels maybe correlated with patient response to drug treatment.

Keywords

Antioxidants
Cutaneous leishmaniasis
Proinflamatory Cytokines
Iranian Journal of Immunology
Volume 9, Issue 3
Summer 2012
Pages 208-214

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