Iranian Journal of Immunology

Anti-Cardiolipin and Anti-Neutrophil Cytoplasmic Antibodies in Iranian Patients with Behcet's Disease

Document Type : Original Article

Authors

Mohammad Reza Ataollahi 1, 2
Elham Aflaki 3, 4
Mohammad Ali Nazarinia 3, 4
Saeedeh Shenavandeh 3, 4
Zahra Habibagahi 3, 4
Behrouz Gharesi-Fard 1, 5
Eskandar Kamali-Sarvestani 1, 4

1 Depatrment of Immunology

2 Student Research Committee

3 Department of Rheumatology

4 Autoimmune Diseases Research Center

5 Infertility Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

https://doi.org/10.22034/iji.2012.16877
Abstract
Background: The prevalence of anti-Neutrophil Cytoplasmic Antibodies (ANCAs) and anti-Cardiolipin Antibodies (anti-CL Ab) in Behcet’s Disease (BD) and also their roles in vascular involvement is controversial.
Objective: To assess the prevalence of ANCAs and anti-CL Ab as well as their correlations with clinical manifestations in Iranian patients with BD.
Methods: In this case/control study, the sera from 88 patients with BD and 88 healthy controls were evaluated. The levels of ANCAs and anti-CL Ab were measured using indirect ELISA method.
Results: The levels of anti-CL, anti-PR3 and anti-MPO (Myeloperoxidase) IgG autoantibodies between BD patients and healthy controls were not statistically different (p=0.21, p=0.28 and p=0.74, respectively). In addition, there were no significant deferences between BD patients with and without vascular involvement in the levels of anti-CL (1.42 ± 1.24 GPLU/ml and 1.58 ± 1.18 GPLU/ml, respectively; p=0.71), anti-PR3 (0.0 ± 0.0 U/ml and 0.08 ± 0.27 U/ml, respectively; p=0.10) and anti MPO (0.48 ± 0.23 U/ml and 0.52 ± 0.22 U/ml, respectively; p=0.41) IgG autoantibodies. Nevertheless, mean titer of anti-CL IgG was higher in male patients with skin rash than those without skin rash (2.2 ± 0.88 GPLU/ml and 1.11 ± 1.22 GPLU/ml, respectively; p=0.017).
Conclusion: While anti-CL, anti- PR3 and anti-MPO IgG autoantibodies do not play a major role in susceptibility to BD or pathogenesis of vascular involvement in our patients, anti-CL Ab might be involved in skin lesion development in Iranian male BD patients. However, the results should be confirmed in other studies.

Keywords

ANCA
Anticardiolipin antibody
Behcet’s Disease
Iranian Journal of Immunology
Volume 9, Issue 4
Autumn 2012
Pages 241-247

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