Iranian Journal of Immunology

Cytokine Status in Ukrainian Children with Irritable Bowel Syndrome Residing in a Radioactive Contaminated Area

Document Type : Original Article

Authors

Mohammad Reza Sheikh Sajjadieh 1, 2
Larisa Kuznetsova 1
vadim Bojenko 2

1 Department of Clinical Immunology and Allergology, National Medical Academy for Post Graduate Education

2 Ukrainian Specialized Dispensaries of Radiation Defend Population, Kiev, Ukraine

https://doi.org/10.22034/iji.2012.16878
Abstract
Background: The effect of low dose radiation on immune system is shown. Ionizing radiation can affect cytokine production and polarization of T helper cells.
Objective: The current study focused on ionizing radiation in Ukrainian children residing in a contaminated area with clinical irritable bowel syndrome.
Method: Our study included 75 rural children population aged 4-18 yrs, who lived in a contaminated area exposed to natural environmental radiation with clinical irritable bowel syndrome (categorized in three groups) and 20 rural children participants aged 5-15 yrs who were living in areas with similar levels of radioactive contamination without clinical irritable bowel syndrome as control group. Internal radiation activity was measured by gamma-ray spectrometry. Serum levels of IL-4 and IFN-γ were measured by enzyme linked immunosorbent assay.
Results: A trend towards increased levels of IL-4 was observed in children with clinical irritable bowel syndrome. In these children, IFN-γ levels were lower than that of the control group.
Conclusion: The IBS symptoms in Ukrainian children residing in a contaminated area may have stemmed from Th1 to Th2 immune deviation and differential expression of IL-4 and IFN-γ.

Keywords

Chernobyl Children
Ionizing radiation
Th2 Response
Irritable bowel syndrome
Iranian Journal of Immunology
Volume 9, Issue 4
Autumn 2012
Pages 248-253

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