Iranian Journal of Immunology

Elevated Levels of Interleukin-23 in Sera of Patients with Pemphigus Vulgaris

Document Type : Short Paper

Authors

Firouz Pouralibaba 1
Zohreh Babaloo 2
Farzaneh Pakdel 1
Tahmoores Abdollahian 1
Solmaz Pourzare 1

1 Department of Oral Medicine, Faculty of Dentistry

2 Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

https://doi.org/10.22034/iji.2012.16880
Abstract
Background: Pemphigus vulgaris, a chronic mucocutaneous disease, is the most prevalent type of pemphigus which manifests with development of bullae and erosions on skin and mucosal membranes.
Objectives: To investigate the potential role of IL-23 in pemphigus vulgaris.
Methods: In this study, 30 patients with pemphigus vulgaris and 30 healthy individuals were selected according to inclusion and exclusion criteria. Measurement of IL-23 serum levels in blood samples was conducted by ELISA. Data was analyzed using Student’s t-test for comparison of IL-23 levels between the two groups.
Results: Mean serum levels of IL-23 in patients with pemphigus and healthy controls were 25.1 ± 4.2 and 17.9 ± 4.7 pg/ml, respectively (p<0.05).
Conclusions: Based on the findings of this study, serum levels of IL-23 were higher in patients with pemphigus in comparison to healthy individuals with no clinical significance.

Keywords

autoimmune disease
Interleukin-23
Pemphigus Vulgaris
Iranian Journal of Immunology
Volume 9, Issue 4
Autumn 2012
Pages 261-265

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