Document Type : Original Article


1 Dr. Lal Pathology Reference Laboratory, New Delhi

2 Department of Ophthalmology, Command Hospital (SC), Pune, India


Background: Uveitis refers to diseases characterized by intraocular inflammation of the uveal tract. Anterior uveitis is a common ocular disease characterized by inflammation of the iris and the ciliary body.
Objectives: To establish the frequency of HLA-B27- positive uveitis in Asian Indian population, study their clinical profile and compare it with other reports in literature.
Methods: We retrospectively reviewed medical data of 89 patients of uveitis referred for HLA B27 typing with predominantly ocular symptoms during the period from April 2006-October 2010. All patients were tested for complete blood count, erythrocyte sedimentation rate, infectious diseases serology, HLA-B27 typing, and prepared radiographs of the sacroiliac joints and lumbar spine if required.
Results: The HLA-B27 positive rate was 56.2% among patients and 3% for control samples. Most of the patients were in the age group of 41-50 years with a male predominance.
Conclusions: HLA-B27 was seen to be associated with acute anterior uveitis in Asian Indian males and the test is important for confirmation of diagnosis, prognostication and also for planning the treatment.