Iranian Journal of Immunology

The Role of Zataria Multiflora Essence (Iranian herb) on Innate Immunity of Animal Model

Document Type : Original Article

Authors

Hojjatollah Shokri 1
Farzad Asadi 2
Ali Reza Bahonar 3
Ali Reza Khosravi 1

1 Mycology Research Centre, Faculty of Veterinary Medicine, Tehran University

2 Department of Biochemistry, Faculty of Veterinary Medicine, Tehran University

3 Department of Epidemiology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran

https://doi.org/10.22034/iji.2006.16998
Abstract
Background: Herbal medicines have been used since ancient times for treatment of a range of diseases and have represented stimulatory effects on the function of innate immunity.
Objective: To evaluate the effects of Zataria multiflora (Z. multiflora) on the function of innate immunity including phagocytic activity and TNF-α secretion in animal model.
Methods: Eight BALB/c mice were divided into two equal groups. In group A, Z. multiflora essence was injected intraperitoneally to the mice, in group B, distilled water was injected. Blood was obtained from 4 mice in each group, 4 and 7 days following injection. The amounts of phagocytosis (respiratory burst) and TNF-α secretion were assessed by chemiluminescence and ELISA method, respectively.
Results: Significant increase in phagocytosis and TNF-α secretion was observed in group A compared with the control group at days 4 and 7.
Conclusion: Z. multiflora essence can remarkably stimulate innate immunity function and it may be used to immunize individuals alone or in combination with other immunostimulatory agents.

Keywords

Zataria multiflora
Phagocytosis
TNF-α
Iranian Journal of Immunology
Volume 3, Issue 4 - Serial Number 11
Autumn 2006
Pages 164-168

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