Iranian Journal of Immunology

Prevalence of Antiphospholipid Antibodies in Syrian Patients with Thrombosis

Document Type : Original Article

Authors

Ali Deeb 1
Said Hamdoun 2
Khaled Dababo 3

1 Department of Internal Medicine

2 Department of Rheumatology

3 Department of Laboratory in Aleppo University, Aleppo, Syria

https://doi.org/10.22034/iji.2009.17087
Abstract
Background: Antiphospholipid antibodies (aPL) are a heterogeneous family of anti-bodies associated with thrombosis and other complications.
Objective: To study the prevalence of aPL in patients with thrombosis at Aleppo University Hospitals, Syria.
Methods: One hundred and fifty-seven patients with venous and arterial thrombosis and 63 healthy controls were studied. Anticardiolipin antibodies (aCL) and Lupus antico-agulant (LA) were determined.
Results: Thirty-four out of 157 (21.7%) patients with thrombosis had some type of aPL. aPL was also found in four healthy subjects (4/63=6.3%). Eighteen patients (11.5%) were positive for LA, 20 (12.7%) for aCL anti-bodies and 4 (2.6%) were positive for more than one aPL. Patients without risk factors for thrombosis and having positive aPL were 23/34 (67.7%). Fourteen out of 78 (17.9%) patients with arterial thrombosis, and 20/79 (25.3%) with venous thrombosis were positive for at least one aPL.
Conclusion: Our study showed a significant preva-lence of aPL in patients with thrombosis. It seems that aPL is a risk factor for venous and arterial thrombosis, especially in patients with no conventional risk factors.

Keywords

Antiphospholipid Antibodies
Anticardiolipin Antibodies
SLE
Iranian Journal of Immunology
Volume 6, Issue 3
Summer 2009
Pages 154-159

Home

Guide for Authors

Submit Manuscript

Guide for Reviewers

Contact Us