Background: Artemisia diffusa contains a new type of sesquiterpene lactone with an endoperoxide group (Tehranolide). Objective: Due to the existing similarity between the structures of Tehranolide and Artemisinin, it was hypothesized that Tehranolide would have similar effects as Artemisinin. In this study, the immunotherapeutic effec-tiveness of Tehranolide was investigated by direct intra-tumoral injection. Methods: Tehranolide was purified from Artemisia diffusa, and its effect on the tumor volume was investigated. The splenocyte proliferation, shifting of cytokine profile, and the presence of naturally-occurring CD4+CD25+Foxp3+ Treg cells were assessed to describe the anti-tumor immune response. Results: Analysis of immune response showed that, intra-tumoral injection of Tehranolide decreased the rate of tumor growth compared to control group. Furthermore, the proliferative response of mice treated with Tehranolide was en-hanced. In comparison with the control group, production of both IL-4 and IFN-γ was in-duced (p<0.05). The results indicated a decrease in tumor CD4+CD25+Foxp3+ T lym-phocytes in the Tehranolide-treated group compared to the control group. Conclusion: Treatment of tumors with Tehranolide attenuated CD4+CD25+Foxp3+ Treg cell-mediated immune suppression and elicited a persistent anti-tumor immunity against can-cer.
Noori, S., Taghikhani, M., M. Hassan, Z., Allameh, A. & Mostafaei, A. (2009). Tehranolide Could Shift the Immune Response towards Th1 and Modulate the Intra-Tumor Infiltrated T Regulatory Cells. Iranian Journal of Immunology, 6(4), 216–224. https://doi.org/10.22034/iji.2009.17095
MLA
Noori, S., Taghikhani, M., M. Hassan, Z., Allameh, A., & Mostafaei, A. "Tehranolide Could Shift the Immune Response towards Th1 and Modulate the Intra-Tumor Infiltrated T Regulatory Cells", Iranian Journal of Immunology, 6, 4, 2009, 216–224. doi: 10.22034/iji.2009.17095
HARVARD
Noori, S., Taghikhani, M., M. Hassan, Z., Allameh, A., & Mostafaei, A. (2009). 'Tehranolide Could Shift the Immune Response towards Th1 and Modulate the Intra-Tumor Infiltrated T Regulatory Cells', Iranian Journal of Immunology, 6(4), pp. 216–224. doi: 10.22034/iji.2009.17095
CHICAGO
Noori, S., Taghikhani, M., M. Hassan, Z., Allameh, A. & Mostafaei, A., "Tehranolide Could Shift the Immune Response towards Th1 and Modulate the Intra-Tumor Infiltrated T Regulatory Cells." Iranian Journal of Immunology, 6 4 (2009): 216–224, doi: 10.22034/iji.2009.17095
VANCOUVER
Noori S., Taghikhani M., M. Hassan Z., Allameh A., Mostafaei A. Tehranolide Could Shift the Immune Response towards Th1 and Modulate the Intra-Tumor Infiltrated T Regulatory Cells. Iran.J.Immunol. 2009;6(4):216–224. doi: 10.22034/iji.2009.17095
