Background: Major Depression Disorder (MDD) is a common disorder with preva-lence of 15% among men and up to 25% among women. In recent years the association of immune system alterations and MDD has been investigated. Assessments of immu-nologic and inflammatory responses in these patients enhance our knowledge of the eti-ology and pathogenesis of this disease. Objective: To investigate the changes in immu-noglobulin and cytokine serum levels and lymphocyte subsets in patients with MDD. Methods: We studied 37 adult patients with MDD, diagnosed based on DSM-IV diag-nostic criteria, and 15 healthy controls matched with the patients. Plasma concentration of interleukin-4 (IL-4), IL-10, TNF α, and IFN γ were measured by ELISA and serum immunoglobulins by SRID. Total number of NK cells (CD16 and CD56), B cells (CD19), and T cells (CD8, CD4, and CD3) were determined by flow cytometry. Results: We found no significant differences in plasma concentration of IL-4, IL-10, TNF-α, IFN-γ, and immunoglobulins as well as total number of NK cells, B cells, and T cells between major depressed patients and healthy control subjects. Conclusion: We conclude that in our patients, there were no significant differences in immune system ac-tivity between MDD patients and controls.
Hosseini, R. F., Jabbari Azad, F., Talaee, A., Miri, S., Mokhber, N., Farid Hosseini, F., Esmaeili, H., Mahmoudi, M., Rafatpanah, H. & Mohammadi, M. (2007). Assessment of the Immune System Activity in Iranian Patients with Major Depression Disorder (MDD). Iranian Journal of Immunology, 4(1), 38–43. https://doi.org/10.22034/iji.2007.17178
MLA
Hosseini, R. F., Jabbari Azad, F., Talaee, A., Miri, S., Mokhber, N., Farid Hosseini, F., Esmaeili, H., Mahmoudi, M., Rafatpanah, H., & Mohammadi, M. "Assessment of the Immune System Activity in Iranian Patients with Major Depression Disorder (MDD)", Iranian Journal of Immunology, 4, 1, 2007, 38–43. doi: 10.22034/iji.2007.17178
HARVARD
Hosseini, R. F., Jabbari Azad, F., Talaee, A., Miri, S., Mokhber, N., Farid Hosseini, F., Esmaeili, H., Mahmoudi, M., Rafatpanah, H., & Mohammadi, M. (2007). 'Assessment of the Immune System Activity in Iranian Patients with Major Depression Disorder (MDD)', Iranian Journal of Immunology, 4(1), pp. 38–43. doi: 10.22034/iji.2007.17178
CHICAGO
Hosseini, R. F., Jabbari Azad, F., Talaee, A., Miri, S., Mokhber, N., Farid Hosseini, F., Esmaeili, H., Mahmoudi, M., Rafatpanah, H. & Mohammadi, M., "Assessment of the Immune System Activity in Iranian Patients with Major Depression Disorder (MDD)." Iranian Journal of Immunology, 4 1 (2007): 38–43, doi: 10.22034/iji.2007.17178
VANCOUVER
Hosseini R. F., Jabbari Azad F., Talaee A., Miri S., Mokhber N., Farid Hosseini F., Esmaeili H., Mahmoudi M., Rafatpanah H., Mohammadi M. Assessment of the Immune System Activity in Iranian Patients with Major Depression Disorder (MDD). Iran.J.Immunol. 2007;4(1):38–43. doi: 10.22034/iji.2007.17178
