Iranian Journal of Immunology

Aqueous Humor Levels of Soluble Fas and Fas-ligand in Patients with Primary Open Angle and Pseudoex-foliation Glaucoma

Document Type : Original Article

Authors

Mohammad Reza Razeghinejad 1, 2
Eskandar Kamali-Sarvestani 3, 4

1 Department of ophthalmology and

2 Poostchi Ophthalmology Research center, Khalili Hospital

3 Department of immunology and

4 Autoimmune diseases Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

https://doi.org/10.22034/iji.2007.17200
Abstract
Background: Glaucoma is one of the most common causes of blindness and is usually associated with elevated intraocular pressure. In patients with primary open angle glau-coma the number of trabecular meshwork cells is decreased. Death of the trabecular meshwork cells may be a result of apoptosis.
Objective: To investigate the aqueous humor levels of soluble Fas (sFas) and Fas-Ligand (sFasL) in glaucomatous patients.
Methods: Concentration of sFas and sFasL were measured by ELISA in 41 eyes with glaucoma (21 with pseudoexfoliation and 20 with primary open angle glaucoma) and 39 eyes with cataract as controls.
Results: The sFas concentration was lower in the pri-mary open angle than the pseudoexfoliation glaucoma and the cataract groups (p=0.002 and p= 0.004, respectively). The sFasL level did not show any significant difference in the three groups.
Conclusion: A lower level of sFas may provide proper microenvironment for increased apoptosis of trabecular meshwork cells in primary open angle glaucoma.

Keywords

apoptosis
Open angle glaucoma
Pseudoexfoliation glaucoma
Soluble Fas
Soluble Fas-ligand
Iranian Journal of Immunology
Volume 4, Issue 4
Autumn 2007
Pages 215-219

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