Document Type : Original Article

Authors

• Maryam Sohrabi ¹
• Mahdi Alahgholi-Hajibehzad ^{2, 3}
• Zahra Gholami Mahmoodian ¹
• Sayed Ali Hosseini Siyar ⁴
• Alireza Zamani ^{2, 3}

¹ Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

² Department of Immunology, School of Medicine,

³ Molecular Immunology Research Group, Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

⁴ Department of Animal Science, Agriculture Faculty, Bu-Ali Sina University, Hamadan, Iran

Abstract

 
Background: Studies have indicated that extraweight and obesity induce chronic inflammation, which can lead to other diseases such as cancers. Objective: To evaluate the effects of two weight-lowering and anti-inflammatory agents including cinnamon, and turmeric, on serum levels of interleukin-17 (IL-17) as a pro-inflammatory cytokine. Methods: In this study, 64 rats were designated in eight groups. The control group received normal diet. The other groups were fed with normal diet plus high cinnamon (3 mg/ml), high turmeric (3 mg/ml), high-fructose solution (30%), fructose solution with low (0.15 mg/ml) and high doses (3 mg/ml) of cinnamon and turmeric three times per week. The serum level of IL-17F was measured by enzyme-linked immunosorbent assay (ELISA). Results: High fructose consumption led to an increase in the weight and serum level of IL-17. While, feeding with cinnamon and turmeric caused to decline weight but, surprisingly increased IL-17F levels. Conclusion: Although, some studies have showed that cinnamon and turmeric supplementation decreased IL-17F under the standard diet, in the presence of high fructose diet and extraweight their effects were reversed and caused an increase in serum level of IL-17F.