Iranian Journal of Immunology

Fetuin A and Interleukin 8 in Children with Clinical Remission of Type 1 Diabetes

Document Type : Original Article

Authors

Aleksandra Pyziak-Skupien 1
Katarzyna Bobeff 2
Krystyna Wyka 2
Katarzyna Banach 2
Beata Malachowska 3
Wojciech Fendler 4
Agnieszka Szadkowska 5
Wojciech Mlynarski 2
Agnieszka Zmyslowska 6

1 Department of Pediatrics, Silesian Medical University in Katowice, Katowice, Poland

2 Department of Pediatrics, Oncology and Hematology, Medical University of Lodz, Poland

3 Department of Biostatistics and Translational Medicine, Medical University of Lodz, Poland

4 Department of Biostatistics and Translational Medicine, Medical University of Lodz, Poland; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA

5 Department of Pediatrics, Diabetology, Endocrinology and Nephrology, Medical University of Lodz, Poland

6 Department of Pediatrics, Diabetology, Endocrinology and Nephrology, Medical University of Lodz, Lodz, Poland

https://doi.org/10.22034/iji.2020.82797.1595
Abstract
Background: Clinical partial remission (CPR) in most patients with type 1 diabetes (T1D) is observed shortly after clinical diagnosis. Increasing body weight and impaired insulin sensitivity may play a role in the pathogenesis of CPR. Several cytokines can also participate in the development of insulin resistance. Objective:To evaluate the relationship between birth weight, body mass index, and the concentrations of IL-8 and Fetuin-A, and the presence of clinical partial remission in children at the T1D onset. Methods:The study group consisted of 134 children with a newly diagnosed T1D in whom the presence of CPR was evaluated in a further 2-year course of diabetes. The control group included 47 children withoutglucose tolerance disorders. The concentrations of IL-8 and Fetuin-A were determined by the ELISA method. Results: CPR occurred in 75.34% of T1D patients. At T1D onset, higher values of BMI SDS in the remitters as compared to the patients without remission were observed. At the T1D onset, the concentrations of Fetuin-A (p=0.031) and IL-8 (p=0.042) were significantly higher in patients compared to those without CPR. Conclusion: Evaluation of Fetuin-A and IL-8 levels in patients with a newly diagnosed T1D can differentiate between patients with or without CPR.

Keywords

BMI
Diabetes Type 1
Fetuin A
Interleukin 8
Remission
Iranian Journal of Immunology
Volume 17, Issue 2
Spring 2020
Pages 144-153

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