Document Type : Original Article
Authors
- Aleksandra Pyziak-Skupien 1
- Katarzyna Bobeff 2
- Krystyna Wyka 2
- Katarzyna Banach 2
- Beata Malachowska 3
- Wojciech Fendler 4
- Agnieszka Szadkowska 5
- Wojciech Mlynarski 2
- Agnieszka Zmyslowska 6
1 Department of Pediatrics, Silesian Medical University in Katowice, Katowice, Poland
2 Department of Pediatrics, Oncology and Hematology, Medical University of Lodz, Poland
3 Department of Biostatistics and Translational Medicine, Medical University of Lodz, Poland
4 Department of Biostatistics and Translational Medicine, Medical University of Lodz, Poland; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
5 Department of Pediatrics, Diabetology, Endocrinology and Nephrology, Medical University of Lodz, Poland
6 Department of Pediatrics, Diabetology, Endocrinology and Nephrology, Medical University of Lodz, Lodz, Poland
Abstract
Background: Clinical partial remission (CPR) in most patients with type 1 diabetes (T1D) is observed shortly after clinical diagnosis. Increasing body weight and impaired insulin sensitivity may play a role in the pathogenesis of CPR. Several cytokines can also participate in the development of insulin resistance. Objective:To evaluate the relationship between birth weight, body mass index, and the concentrations of IL-8 and Fetuin-A, and the presence of clinical partial remission in children at the T1D onset. Methods:The study group consisted of 134 children with a newly diagnosed T1D in whom the presence of CPR was evaluated in a further 2-year course of diabetes. The control group included 47 children withoutglucose tolerance disorders. The concentrations of IL-8 and Fetuin-A were determined by the ELISA method. Results: CPR occurred in 75.34% of T1D patients. At T1D onset, higher values of BMI SDS in the remitters as compared to the patients without remission were observed. At the T1D onset, the concentrations of Fetuin-A (p=0.031) and IL-8 (p=0.042) were significantly higher in patients compared to those without CPR. Conclusion: Evaluation of Fetuin-A and IL-8 levels in patients with a newly diagnosed T1D can differentiate between patients with or without CPR.
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