Iranian Journal of Immunology

DNA Based Vaccines against Mycobacterium Tuberculosis: Recent Progress in Vaccine Development and Delivery System

Document Type : Review Article

Author

Ahmad Mobed

1 Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, 5166615556, Iran. 2Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

https://doi.org/10.22034/iji.2020.87480.1806
Abstract
Tuberculosis (TB) is believed to be one of the leading causes of death in the world; nevertheless, Bacillus Calmette-Guérin (BCG) is the solitary vaccine utilized to prevent TB. Despite the protective effect of this vaccine in children, its efficiency remains under question in adults. We conducted the present study to provide an overview of DNA based vaccines against TB and highlight the vaccine delivery advances and limitations. This study also aimed to bring a review of mycobacterial antigens, including heat shock protein 65 (Hsp65), antigen 85A (Ag85A), early secretory antigenic target 6 (EAST-6), antigen 85B (Ag85B), and heat shock protein X (HspX) as the most extensively considered antigens in the development of vaccines against M. tuberculosis.

Keywords

DNA Vaccine
Mycobacterium Tuberculosis
Mycobacterial Antigen
Vaccine Delivery
Iranian Journal of Immunology
Volume 17, Issue 4
Autumn 2020
Pages 255-274

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