Document Type : Short Communication
Authors
- German Reynaldo Jiménez-Gastélum 1
- Arely Monserrant Espinoza-Ortega 2
- Rosalío Ramos-Payán 3
- Maribel Aguilar-Medina 3
- Jorge López-Gutiérrez 4
- Carlos Villegas-Mercado 5
- Luis Antonio Ochoa-Ramirez 6
- Horacio Rendón-Aguilar 6
- Juan Fidel Osuna-Ramos 7
- Juan José Ríos-Tostado 8
- Jesús Salvador Velarde-Félix 9
1 Facultad de Biología, Universidad Autónoma de Sinaloa (UAS), Culiacán, Sinaloa, México.
2 Hospital General de Culiacán, “Bernardo J Gastélum”, Servicios de Salud de Sinaloa, Culiacán, Sinaloa, México
3 Facultad de Ciencias Químico Biológicas, UAS, Culiacán, Sinaloa, México.
4 Facultad de Biología, UAS, Culiacán, Sinaloa, México.
5 Facultad de Odontología, UAS, Culiacán, Sinaloa, México.
6 Hospital General de Culiacán, “Bernardo J Gastélum”, Servicios de Salud de Sinaloa, Culiacán, Sinaloa, México.
7 Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Ciudad de México, México.
8 Facultad de Biología, UAS, Culiacán, Sinaloa, México; Hospital General de Culiacán, “Bernardo J Gastélum”, Servicios de Salud de Sinaloa, Culiacán, Sinaloa, México.
9 Facultad de Biología, UAS; Hospital General de Culiacán, “Bernardo J Gastélum”, Servicios de Salud de Sinaloa, Culiacán, Sinaloa, México.
Abstract
Background: According to the World Health Organization, Mexico presents one of the highest mortality rates due to coronavirus disease 2019 (COVID-19). The "cytokine storm" phenomenon has been proposed as a pathological hallmark of severe COVID-19. Objective: To determine the association of serum cytokine levels with COVID-19 severity. Methods: We studied the cytokines IL-2, IL-4, IL-6, IL-10, TNF-α, and the IFN-γ serum levels through flow cytometry in 56 COVID-19 patients (24 critical and 32 non-critical) from Northwest Mexico. Results: We observed a significant increase in the IL-6 and the IL-10 levels in the sera of critical patients. These cytokines were also associated with mechanical ventilation necessity and death, IL-6 showing AUC values above 0.7 for both variables; and correlated with Na+, creatinine, and platelet levels. On the other hand, no association was found between IL-2, IL-4, TNF-α, and IFN-γ with tested variables. Conclusion: Our results corroborate previous observations regarding IL-6 and IL-10 involvement in the severity of COVID-19.
Keywords
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