Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
1. Islet Amyloid Polypeptide is not a Target Antigen for CD8+ T-Cells in Type 2 Diabetes

Fathollah Kalantar; Mohammad Hossein Dabbaghmanesh; Emanuela Martinuzzi; Mohsen Moghadami; Zahra Amirghofran

Volume 11, Issue 1 , Winter 2014, , Pages 1-12

  Background: Type 2 diabetes (T2D) is a chronic metabolic disorder in which beta-cells are destroyed. The islet amyloid polypeptide (IAPP) produced by beta-cells has been reported to influence beta-cell destruction. Objective: To evaluate if IAPP can act as an autoantigen and therefore, to see if CD8 ...  Read More

2. Immunoinhibitory Effect of Teuclatriol a Guaiane Sesquiterpene from Salvia mirzayanii

Akram Ziaei; Zahra Amirghofran; Josef Zapp; Mohammad Ramezani

Volume 8, Issue 4 , Autumn 2011, , Pages 226-235

  Background: Salvia mirzayanii, a native plant to Iran, is shown to have immunomodulatory effects on lymphocyte proliferation. Objective: To identify the bioactive immunomodulatory compound(s) present in S. mirzayanii. Methods: The crude extract was fractionated to five fractions in two steps using different ...  Read More

3. Inhibition of Nitric Oxide Production and Proinflammatory Cytokines by Several Medicinal Plants

Zahra Amirghofran; Saeed Malek-Hosseini; Hossein Golmoghaddam; Fathollah Kalantar; Mehdi Shabani

Volume 8, Issue 3 , Summer 2011, , Pages 159-169

  Background: A number of medicinal plants have been used to treat various immunological diseases. Nitric oxide (NO) has an important regulatory role in the various types of inflammatory processes. Objective: To investigate the NO modulatory activity of the extracts of several medicinal plants native to ...  Read More

4. Haussknechtia Elymatica: A Plant with Immunomodulatory Effects

Zahra Amirghofran; Abbas Azadmehr; Katayoun Javidnia

Volume 4, Issue 1 , Winter 2007, , Pages 26-31

  Background: Plant extracts have been widely investigated for possible immunomodu-latory properties. Objective: To study the immunomodulatory functions of the metha-nol extract of Haussknechtia elymatica (Apioideae), an herb native to south-western Iran. Methods: Delayed type hypersensitivity (DTH) skin ...  Read More

5. The Influence of Perforin Expression on the Sensitivity of LAK/NK Killing Against Various Tumor Target Cells

Zahra Amirghofran

Volume 2, Issue 1 , Winter 2005, , Pages 29-35

  Background: Perforin is known to be important in cytolytic activity mediated by natural killer (NK) cells.   Objective: To study the relationship between the efficiency of NK and lymphokine-activated killer (LAK) cells activity, and the expression of perforin and HLA class I molecules.   Methods: ...  Read More

6. p53 Protein Expression and Its Relation to the Apoptotic Index in Prostate Adenocarcinoma

Nasser Gholijani; Ahmad Monabati; Zahra Amirghofran

Volume 1, Issue 1 , Spring 2004, , Pages 34-40

  Background: Prostate cancer is one of the most commonly diagnosed cancers in males. Tumor suppressor gene p53 plays an important role in causing cell cycle arrest and allowing apoptosis to proceed. Objective: To investigate the expression of p53 protein and its relation to apoptosis and prostate cancer ...  Read More