Elevated Levels of Interleukin-23 in Sera of Patients with Pemphigus Vulgaris

Document Type: Short Paper

Authors

1 Department of Oral Medicine, Faculty of Dentistry

2 Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Background: Pemphigus vulgaris, a chronic mucocutaneous disease, is the most prevalent type of pemphigus which manifests with development of bullae and erosions on skin and mucosal membranes.
Objectives: To investigate the potential role of IL-23 in pemphigus vulgaris.
Methods: In this study, 30 patients with pemphigus vulgaris and 30 healthy individuals were selected according to inclusion and exclusion criteria. Measurement of IL-23 serum levels in blood samples was conducted by ELISA. Data was analyzed using Student’s t-test for comparison of IL-23 levels between the two groups.
Results: Mean serum levels of IL-23 in patients with pemphigus and healthy controls were 25.1 ± 4.2 and 17.9 ± 4.7 pg/ml, respectively (p<0.05).
Conclusions: Based on the findings of this study, serum levels of IL-23 were higher in patients with pemphigus in comparison to healthy individuals with no clinical significance.

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