Volume 20 (2023)
Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)

Aim and scope:
The Iranian Journal of Immunology (I.J.I) is an internationally disseminated peer-reviewed publication and publishes a broad range of experimental and theoretical studies concerned with all aspects of immunology.


Types of papers accepted:
The Journal will welcome original and review articles on basic and clinical Immunology, Immunogenetics, Transplantation Immunology, Immunohematology, Cancer Immunology, and Allergy. The Journal will also welcome short papers and letters to the Editor.


Iranian Journal of Immunology is indexed in the following indexing systems: 

  • MEDLINE
  • Web of Science (ISI)
  • SCOPUS
  • EMBASE
  • EMNursing
  • GEOBASE
  • Cambridge Scientific Abstracts
  • Chemical Abstracts
  • Global Health
  • Index Medicus for Eastern Mediterranean Region (IMEMR)

IJI, is an official publication of the Iranian Society for Immunology and Allergy (ISIA), which is published by Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences (SUMS), Shiraz, Iran.

Original Article
JAK/STAT Signaling Pathway Mediates Anti-Tumor Immunity of CD8+ T Cells in Renal Cancer

Jia Shao; Gang Deng; Guojun Wen; Xi Xie

Volume 21, Issue 3 , September 2024, Pages 186-200

https://doi.org/10.22034/iji.2024.103692.2852

Abstract
  Background: CD8+ T cells play a crucial role in immune responses, and have significant potential in tumor immunotherapy. The JAK/STAT pathway is essential for cytokine signal transduction and is linked to immune escape. However, its role in mediating CD8+ T cell anti-tumor immunity in renal cancer is ...  Read More

Original Article
miR-196b-5p Affects Macrophage Polarization and Inflammation in Endometriosis

Zhe Xue; Yuyan Guo; Fangyun Wang; Qinping Yang; Qiuhong Chen; Tingting Lin; Shunhe Lin

Volume 21, Issue 3 , September 2024, Pages 201-211

https://doi.org/10.22034/iji.2024.102744.2794

Abstract
  Background: miR-196b-5p was found to be significantly reduced in endometriosis, but its function and the mechanisms involved remained unclear.Objective: To explore the effect of miR-196b-5p on manipulating macrophage phenotype and the underlying mechanisms in endometriosisMethods: The endometriosis mice ...  Read More

Original Article
Modulation of M1/M2 Cytokines and Inflammatory Enzymes by Persicaria Species Leaf Extracts in Lipopolysaccharide-stimulated RAW 264.7 Cell Macrophages

Adamu Imam Isa

Volume 21, Issue 3 , September 2024, Pages 212-224

https://doi.org/10.22034/iji.2024.102221.2780

Abstract
  Background: Investigating the impacts of plant-based substances on the regulation of pro-inflammatory M1 and anti-inflammatory M2 cytokines could have significant implications for immune-related health conditions. Seven Persicaria plant species from sub-Saharan Africa were specifically selected for analysis, ...  Read More

Original Article
The Protective Role of IL-17 and IL-22 in COVID-19 Infection

Sengul Aksakal; Selim Gorgun

Volume 21, Issue 3 , September 2024, Pages 225-233

https://doi.org/10.22034/iji.2024.100909.2721

Abstract
  Background: The development of a cytokine storm in Coronavirus Disease 2019 (COVID-19) infection can make the disease fatal. We hypothesize that this excessive cytokine production impairs mucosal healing. IL-17 and IL-22 are cytokines that play a key role in protecting and regenerating mucosal tissues. ...  Read More

Original Article
Prognostic Value of CD14 Expression in Peripheral Blood Mononuclear Cell Membrane in Patients with Severe COPD Complicated with Pulmonary Infection

Ruiping Li; Wei Song; Donglan Mei

Volume 21, Issue 3 , September 2024, Pages 234-242

https://doi.org/10.22034/iji.2024.102320.2783

Abstract
  Background: Severe chronic obstructive pulmonary disease (COPD) patients with pulmonary infections face higher morbidity and mortality.Objective: To investigate mononuclear cell membrane CD14 as a prognostic marker for their outcome.Methods: A total of 311 participants were included: 122 in the coinfection ...  Read More

Original Article
The Impact of Wharton’s Jelly-derived Exosomes on the Production of Inflammatory Mediators from HIG-82 Synoviocytes

Ali Fotouhi; Maryam Hosseini; Ali Aghebati-Maleki; Mohammad Sadegh Soltani-Zangbar; Sara Parsania; Amirhossein Mardi; Leili Aghebati-Maleki

Volume 21, Issue 3 , September 2024, Pages 243-254

https://doi.org/10.22034/iji.2024.101823.2760

Abstract
  Background: Osteoarthritis (OA) is the most common joint disease worldwide. Routine treatment options are limited, and total knee replacement surgeries often come with complications. In recent years, the use of biologics, such as Wharton’s jelly (Wj) derived from the umbilical cord (UC), has gained ...  Read More

Case Report
IgG4-Related Disease in a 90-Year-Old Man with an 18-Year Disease Course: A Case Report

Qitao Ren; Ying Jin; Guangxin Zhou; Qiaoxiang Yin; Ping Liu; Yanjie Cao; Yongmin Bi

Volume 21, Issue 3 , September 2024, Pages 255-260

https://doi.org/10.22034/iji.2024.103289.2828

Abstract
  IgG4-related disease (IgG4-RD) is a multi-organ inflammatory immune-mediated illness caused by IgG4-secreting plasma cells infiltrating the tissue. This condition usually affects elderly men. A 90-year-old Chinese male was diagnosed with IgG4-RD based on the new 2019 ACR/EULAR classification criteria, ...  Read More

The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis

Min Lin; Jin Huang; Wei-Chang Chen; Zhi-Ning Fan; Xihu Qin

Volume 17, Issue 1 , March 2020, , Pages 52-63

https://doi.org/10.22034/iji.2020.80294

Abstract
  Background: Tim-3 has been considered as an ideal target for the immunotherapy of inflammation, but it is unclear whether Tim-3 also plays an important role in acute pancreatitis (AP), as well. Objective: To identify the immunomodulatory effects and mechanisms of Tim-3 action in the early stages of severe ...  Read More

Pathogenesis of Atopic Dermatitis: Current Paradigm

Masutaka Furue; Dugarmaa Ulzii; Yen Vu; Gaku Tsuji; Makiko Kido-Nakahara; Takeshi Nakahara

Volume 16, Issue 2 , June 2019, , Pages 97-107

https://doi.org/10.22034/iji.2019.80253

Abstract
  Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles ...  Read More

Expression of Human Cytokine Genes Associated with Chronic Hepatitis B Disease Progression
Volume 14, Issue 4 , December 2017, , Pages 281-292

Abstract
  Background: Hepatitis viruses are non-cytopathic viruses that lead to the infection and pathogenesis of liver diseases as a result of immunologically mediated event. Objective: To investigate the expression of human inflammatory cytokines in chronic hepatitis B patients according to the severity of the ...  Read More

Role of Interleukin-37 in Inflammatory and Autoimmune Diseases

Xiaoying Wang; Keye Xu; Sisi Chen; Yan Li; Mingcai Li

Volume 15, Issue 3 , September 2018, , Pages 165-174

https://doi.org/10.22034/iji.2018.39386

Abstract
  Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 suppression. IL-37 also translocates to the cell ...  Read More

Publisher:
Shiraz Institute for Cancer Research

Editor-in-Chief:
Abbas Ghaderi, Distinguished Professor of Immunology

Associate Editor:
Fereshteh Mehdipour, MD, Ph.D.

Managing Editor:
Mahyar Malekzadeh, Ph.D. Candidate

Executive Assistant:
Hamid Ghaderi, DDS

Editorial Board:
Mosayebi G.


Frequency: Quarterly

Print ISSN: 1735-1383

Online ISSN: 1735-367X

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