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Volume 21 (2024)
Volume 20 (2023)
Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Review Article
Interaction Between Tfh/Tfr Ratio and Regulatory B Cell in Autoimmune Diseases

Chunhong Zhu; Xiaoying Ni; Jiangming Xu; Hao Wang; Hongqiang Shen

Volume 22, Issue 1 , March 2025, Pages 1-1

https://doi.org/10.22034/iji.2025.103848.2859

Abstract
  The balance between follicular helper T cells (Tfh) and follicular regulatory T cells (Tfr) is crucial for maintaining immune tolerance. Tfh cells are key in producing autoantibodies by providing essential help to germinal center (GC) B cells, while Tfr cells prevent autoimmune inflammatory processes ...  Read More

Original Article
Transmembrane TNF-α Reverse Signaling Alleviates Lipopolysaccharide-induced ‎Inflammation by Regulating the MCPIP1/SIRT1/NF-κB Pathway

Chenxi Li; Mingxin Lin; Xiujuan Li; Lijin Chen; Yubin Lin; Huiming Ye

Volume 22, Issue 1 , March 2025, Pages 2-2

https://doi.org/10.22034/iji.2025.104371.2907

Abstract
  Background: Studies have demonstrated that transmembrane tumor necrosis factor-α (tmTNF-α) plays an anti-inflammatory role. tmTNF-α has a dual function, acting as both a signaling ligand and a receptor that transmits reverse signaling to cells expressing tmTNF-α. However, the ...  Read More

Original Article
CX3CR1 Functions as a Biomarker Associated with Pathological Tumor Staging in ‎the Diagnosis and Prognosis of Prostate Cancer

Shiquan Xu; Qing Liu; Jie Wang; Zeyun Zhang; Ying Wang; Li Li; Tao Zhang; Yu Fan

Volume 22, Issue 1 , March 2025, Pages 3-3

https://doi.org/10.22034/iji.2025.104018.2876

Abstract
  Background: Previous research has identified several potential biomarkers associated with pathological tumor (pT) staging in prostate cancer (PCa) patients. Among these biomarkers, CX3CR1 is notable for its connection to the immune microenvironment.Objective: To further investigate the significance of ...  Read More

Original Article
MicroRNA-146a Inhibits Progression and Immune Evasion in Diffuse Large B-cell Lymphomas by Targeting Programmed Cell Death Ligand 1

Yan Li; Xiang Wang; Kuannv Yang

Volume 22, Issue 1 , March 2025, Pages 4-4

https://doi.org/10.22034/iji.2025.104027.2874

Abstract
  Background: Earlier studies have highlighted the involvement of miRNA146a in tumor suppression indicating its potential to inhibit the progression of diffuse large B-cell lymphoma (DLBCL).Objective: To identify programmed death-ligand 1 (PD-L1) as a candidate for further research, as it plays a key role ...  Read More

Original Article
Low-dose Radiation Improves Tumor Immune Microenvironment, Enhancing the Effects of Anti-CTLA-4 Therapy

Jigang Dong; Ying Qi; Sha Sha

Volume 22, Issue 1 , March 2025, Pages 5-5

https://doi.org/10.22034/iji.2025.103258.2825

Abstract
  Background: Radiotherapy destroys tumor cells primarily through direct DNA damage by high-energy particles or indirect DNA damage by free radicals. High-dose radiotherapy (HDR) destroys tumor cells while also damaging normal cells and may potentially cause immunosuppression. The effect of low-dose radiotherapy ...  Read More

Original Article
circ_0001006 Promotes Immune Escape in Non-small Cell Lung Cancer by Regulating the miR-320a/PD-L1 Axis

Zhenying Geng; Guoqing Zhang

Volume 22, Issue 1 , March 2025, Pages 6-6

https://doi.org/10.22034/iji.2025.102661.2792

Abstract
  Background: Circular RNAs are involved in the tumorigenesis of various tumors, including Non-small cell lung cancer (NSCLC).Objective: To investigate the expression of circ_0001006 in patients with NSCLC and its role in tumorigenesis and immune escape.Methods: A total of 115 patients with NSCLC were ...  Read More

Original Article
Evaluation of Dendritic Cell Subpopulations Frequency in COVID-19 Patients and their Correlation with Disease Severity

Vahid Asghariazar; Majid Eterafi; Somaieh Matin; Nasrin Fouladi; Rozita Abolhasani; Monireh Falsafi; Afshin Fathi; Elham Safarzadeh

Volume 22, Issue 1 , March 2025, Pages 7-7

https://doi.org/10.22034/iji.2025.104236.2887

Abstract
  Background: COVID-19 (2019) clearly demonstrates an imbalanced immune response. Variations in the function and subtypes of dendritic cells (DCs) may have effects on immune responses in COVID-19 patients and contribute to immunopathology.Objectives: To assess the phenotype and frequency of Plasmacytoid ...  Read More

Short Paper
Soluble HLA-E and Gastroesophageal Reflux Disease: A Novel Association‎

Huda Saleem Hantoosh Hameed Al-khalidy; Wafaa Hazim Salih‎; Batool Mutar Mahdi

Volume 22, Issue 1 , March 2025, Pages 8-8

https://doi.org/10.22034/iji.2025.104717.2915

Abstract
  Background: Gastroesophageal reflux disease (GERD) is a prevalent clinical condition that affects millions of individuals worldwide.Aim of the study: To assess the level of soluble HLA-E (sHLA-E) as a biomarker in the diagnosis and immunopathogenesis of GERD patients.Materials and methods: The case-control ...  Read More

Original Article
Evaluation of Patients with Combined Immunodeficiency: A Single Center Experience

Hatice Firatoglu; Caner Aytekin; Figen Dogu; Sevgi Kostel Bal; Sule Haskologlu; Kaan Boztug; Aydan Ikinciogullari

Volume 22, Issue 1 , March 2025, Pages 9-9

https://doi.org/10.22034/iji.2025.103499.2844

Abstract
  Background: Severe combined immunodeficiency (SCID) is the most severe form of inborn errors of immunity (IEIs) and typically leads to death within the first year of life. Combined immunodeficiencies (CID) are immune disorders that are less severe than SCID and are characterized by qualitative or quantitative ...  Read More