Mansour Rahimi; Seyed Sahabaldin Shahrzad; Mohammad Banifatemi
Volume 9, Issue 2 , June 2012, , Pages 136-144
Abstract
Background: Cystoid Macular Edema (CME) is one of the most common and sight threatening complications of uveitis. Intravitreal injection of corticosteroids and anti-VEGF antibody are two routine options for treatment. Objective: To compare the effects of intravitreal injections of Bevacizumab and Triamcinolone ...
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Background: Cystoid Macular Edema (CME) is one of the most common and sight threatening complications of uveitis. Intravitreal injection of corticosteroids and anti-VEGF antibody are two routine options for treatment. Objective: To compare the effects of intravitreal injections of Bevacizumab and Triamcinolone Acetonide for the treatment of persistent macular edema in non-infectious uveitis. Methods: In a randomized clinical trial, sixty eyes of 55 patients were enrolled in the study. Patients were divided into two groups with randomized digits table. 29 eyes received 4 mg of intravitreal triamcinolone acetonide, and 31 eyes received 1.25 mg of intravitreal bevacizumab. Two main outcome measures were changes in visual acuity, measured with logarithm of minimal angle of resolution, and central macular thickness, measured with optical coherence tomography. Results: The mean follow-up was 25.3 weeks. The best visual acuities were achieved 6 months after injection in both groups. Improvement in visual acuity at 6 months was achieved in 28/29 (96%) of eyes in Triamcinolone group and in 26/31 (83%) eyes in Bevacizumab group (p=0.196). None of the eyes showed worsening of visual acuity after 6 months. Mean of central macular thickness in the pre-injection time for intravitreal triamcinolone acetonide (IVTA) group was 295.62 μ, and 309.87 μ in intravitreal bevacizumab (IVB) group, which were decreased after six months to 199.27 μ and 221.06 μ, respectively (p<0.001). Conclusion: This study shows that IVT and IVB are both effective in improving vision in uveitic CME. Although effects of triamcinolone on Central Macular Thickness (CMT) are more apparent, this superiority is not seen on Best Corrected Visual Acuity (BCVA).
Mahendra Narin Mishra; Khurshed Minoo Bharucha
Volume 8, Issue 2 , June 2011, , Pages 85-89
Abstract
Background: Uveitis refers to diseases characterized by intraocular inflammation of the uveal tract. Anterior uveitis is a common ocular disease characterized by inflammation of the iris and the ciliary body. Objectives: To establish the frequency of HLA-B27- positive uveitis in Asian Indian population, ...
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Background: Uveitis refers to diseases characterized by intraocular inflammation of the uveal tract. Anterior uveitis is a common ocular disease characterized by inflammation of the iris and the ciliary body. Objectives: To establish the frequency of HLA-B27- positive uveitis in Asian Indian population, study their clinical profile and compare it with other reports in literature. Methods: We retrospectively reviewed medical data of 89 patients of uveitis referred for HLA B27 typing with predominantly ocular symptoms during the period from April 2006-October 2010. All patients were tested for complete blood count, erythrocyte sedimentation rate, infectious diseases serology, HLA-B27 typing, and prepared radiographs of the sacroiliac joints and lumbar spine if required. Results: The HLA-B27 positive rate was 56.2% among patients and 3% for control samples. Most of the patients were in the age group of 41-50 years with a male predominance. Conclusions: HLA-B27 was seen to be associated with acute anterior uveitis in Asian Indian males and the test is important for confirmation of diagnosis, prognostication and also for planning the treatment.
