Document Type : Short Paper
Authors
- Tawfik Jasim Mohammad Al-Marzook
- Batool Mutar Mahdi
- Hyam Raouf
- Haider Hashim Zalzala
- Laheeb Ali Abid
- Zena Nehad
Department of Microbiology, Al-Kindy College of Medicine, Baghdad University, Baghdad, Iraq
Abstract
Background: Cholecystitis is one of the major digestive diseases. Its prevalence is particularly high in some populations. Significant risk factors associated with cholecystitis include age, sex, obesity, diet, parity and type 2 diabetes.
Objective: To determine the association between HLA-DRB1 and cholecystitis.
Methods: This casecontrol study included forty Iraqi Arab patients who had cholecystitis with multiple calculi treated by cholecystectomy admitted in the surgical ward at Al-Kindy Teaching Hospital Baghdad between September -2013 to June -2014. The control group consisted of forty healthy volunteers among the staff of Al-Kindy College of Medicine. Control and cholecystitis patients groups were typed for identifying the DRB1* alleles using DNA-based methodology (PCR-SSOP).
Results: There was an increased frequency of HLA-DRB1*0301 in patients with cholecystitis compared with healthy controls (p=0.0442, odd ratio=4.1111, 95% CI: 1.0372-16.2949).
Conclusion: HLADRB1*0301, as a genetic factor, seems to have an association with cholecystitis.
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