Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Original Article
1. Influence of 1 Alpha, 25-Dihydroxyvitamin D3 on T Helper 17 Cells and Related Cytokines in Systemic Lupus Erythematosus

Hadi Reihani; Maryam Rastin; Mahmoud Mahmoudi; Mohsen Ghoryani; Nafiseh Abdollahi; Nafiseh Sadat Tabasi; Shahrzad Zamani Taghizadeh Rabe; Maryam Sahebari

Volume 12, Issue 2 , Spring 2015, Pages 82-93

  Background: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Emerging data suggests that T helper 17 (Th17) cells play a pathogenic role in SLE and the increased number of these cells correlates with disease activity. In recent years, 1α, 25-dihydroxyvitamin D3 (1,25VitD3) ...  Read More

Original Article
2. Effect of Neutrophils on Nitric Oxide Production from Stimulated Macrophages

Eric Adua; Frank Oteng Danso; Oswald Mensah Boa-Amponsem; Frank Adusei-Mensah

Volume 12, Issue 2 , Spring 2015, Pages 94-103

  Background: During the initial phase of an infection, there is an upregulation of inducible nitric oxide synthase in the macrophages for the production of nitric oxide. This is followed by the recruitment of polymorphonuclear leukocytes (neutrophils) which release arginase. Arginase competes with inducible ...  Read More

Original Article
3. Lipopolysaccharide Induced Activation of Toll Like Receptor 4 in Isolated Rat Heart Suggests a Local Immune Response in Myocardium

Maryam Rameshrad; Nasrin Maleki-Dizaji; Haleh Vaez; Hamid Soraya; Ailar Nakhlband; Alireza Garjani

Volume 12, Issue 2 , Spring 2015, Pages 104-116

  Background: Myocardial dysfunction is one of the major complications in patients with sepsis where there is a relationship between the blood level of cytokines and the onset of myocardial depression. In many cases of sepsis, the presence of Lipopolysaccharide (LPS) has been established. LPS Binding Protein ...  Read More

Original Article
4. Investigating the Association of IL-17A and IL-17F with Susceptibility to Pre-eclampsia in Iranian Women

Fahimah Anvari; Feryal Dabagh-Gorjani; Mohammad-Sadegh SoltaniZangbar; Eskandar Kamali-Sarvestani; Zahra Malek-Hosseini; Behrouz Gharesi-Fard

Volume 12, Issue 2 , Spring 2015, Pages 117-128

  Background: Pre-eclampsia (PE) is one of the most important and life-threatening pregnancy disorders that affect at least 3-5% of all pregnancies. Imbalance in helper T cell functions may play a role in predisposing to PE or severity of the disease. Elevated frequencies of Th17 cells in the peripheral ...  Read More

Original Article
5. Increased Expression of Two Alternative Spliced Variants of CD1d Molecule in Human Gastric Cancer

Nasim Hafezi; Abolghasem Ajami; Touraj Farazmandfar; Vahid Hosseini; Reza Alizadeh-Navaei; Mohsen Tehrani

Volume 12, Issue 2 , Spring 2015, Pages 129-140

  Background: CD1d presents glycolipid antigens to invariant natural killer T (iNKT) cells. The role of CD1d in the development of peptic ulcer and gastric cancer has not been revealed, yet. Objective: To clarify the expression of alternatively spliced variants of CD1d in peptic ulcer and gastric cancer. ...  Read More

Case Series
6. Childhood Autoimmune Hepatitis in Bahrain: a Tertiary Center Experience

Eman Farid; Hasan M Isa; Mohamed Al Nasef; Rawia Mohamed; Huda Jamsheer

Volume 12, Issue 2 , Spring 2015, Pages 141-148

  Background: Autoimmune hepatitis (AIH) in childhood has variable modes of presentation, and the disease should be suspected and excluded in all children presenting with symptoms and signs of prolonged or severe acute liver disease. In AIH, the liver biopsy histopathology shows inflammation in addition ...  Read More

Short Paper
7. The Effect of HLA-DRB1 on Cholecystitis

Tawfik Jasim Mohammad Al-Marzook; Batool Mutar Mahdi; Hyam Raouf; Haider Hashim Zalzala; Laheeb Ali Abid; Zena Nehad

Volume 12, Issue 2 , Spring 2015, Pages 149-155

  Background: Cholecystitis is one of the major digestive diseases. Its prevalence is particularly high in some populations. Significant risk factors associated with cholecystitis include age, sex, obesity, diet, parity and type 2 diabetes. Objective: To determine the association between HLA-DRB1 and cholecystitis. ...  Read More