Iranian Journal of Immunology

Association between HLA-DQB1*03:01 and Bullous Pemphigoid in Iranian Patients

Document Type : Original Article

Authors

Nafiseh Esmaili 1, 2
Hossein Mortazavi 1, 2
Sheyda Chams-Davatchi 1, 2
Maryam Daneshpazhoooh 1, 2
Maede Rayati Damavandi 1, 2
Zeinab Aryanian 1, 2
Ali Akbar Amirzargar 3

1 Autoimmune Bullous Diseases Research Center

2 Department of Dermatology, Razi Hospital

3 Molecular Immunology Research Center and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

https://doi.org/10.22034/iji.2013.16798
Abstract
Background: A common Human Leukocyte Antigen (HLA) class II allele, DQβ1*03:01, seems to be associated with Bullous pemphigoid (BP) in Caucasians whereas previous studies in other ethnic groups showed other HLA class II alleles as genetic predisposing factors for BP.
Objective: To investigate the association of HLA class II alleles and haplotypes with BP in Iranian population.
Methods: Fifty patients with Bullous pemphigoid and 180 geographically matched, healthy individuals as control group enrolled into this study. HLA typing of class II (DR and DQ alleles) was carried out using polymerase chain reaction based on sequence-specific primers method.
Results: Class II DQA1 and DQB1 typing showed a significantly higher frequency of HLA-DQA1*05:01 (45% vs. 33%, p=0.03), HLA-DQB1*03:01 (36% vs. 23.6%, p=0.02) and HLA-DQB1*04:01 (4% vs. 1.6%, p=0.04) in the BP patients compared with controls. For DRB1 allele frequencies, there were no significant disease associations. The frequency of DRB1*08:01/DQA1*05:01/DQB1*03:01 (3% vs. 0%, p=0.02) haplotype showed an increase among patients compared with controls.
Conclusion: Our data suggest that Iranian patients with BP present the same genetic predisposition linked to HLA-DQB1*03:01 previously reported in Caucasians.

Keywords

Bullous Pemphgoid
Haplotype
HLA Class II Alleles
Iranian
Iranian Journal of Immunology
Volume 10, Issue 1
Winter 2013
Pages 1-9

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